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DNA Strand Break

A DNA Strand Break involves one or more disruptions of the covalent linkages among phosphodeoxyribose moieties within the sugar-phosphate backbone in… 
National Institutes of Health

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Related topics

17 relations
4'-deoxy-4'-iododoxorubicin9-aminocamptothecinBromodeoxyuridineChromosome Structures

Papers overview

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2011
2011
Photogeneration of reactive oxygen species and photoinduced plasmid DNA cleavage by novel synthetic chalcones.
2008
2008
Identification of a DNA processing complex from Deinococcus radiodurans.
An efficient DNA strand break repair contributes to the radioresistance of Deinococcus radiodurans, which harbors the DNA repair… 
Highly Cited
2007
Highly Cited
2007
XRCC1 Stimulates Polynucleotide Kinase by Enhancing Its Damage Discrimination and Displacement from DNA Repair Intermediates*
Human polynucleotide kinase (hPNK) is required for processing and rejoining DNA strand break termini. The 5′-DNA kinase and 3… 
Highly Cited
2004
Highly Cited
2004
Poly(ADP-ribose) Reactivates Stalled DNA Topoisomerase I and Induces DNA Strand Break Resealing*
Regulating the topological state of DNA is a vital function of the enzyme DNA topoisomerase I. However, when acting on damaged… 
1992
1992
Repair of DNA strand breaks at hyperthermic temperatures in Chinese hamster ovary cells.
The repair of DNA double-strand breaks was measured by pH 7.2 filter elution in cells incubated at 25-45 degrees C either before… 
Highly Cited
1989
Highly Cited
1989
Monofunctional alkylating agent-induced S-phase-dependent DNA damage.
1989
1989
Nick translation detection in situ of cellular DNA strand break induced by radiation.
DNA strand break in HeLa cells induced by radiation was detected using the in situ nick translation method. The cells were… 
1984
1984
β-Lapachone greatly enhances MMS lethality to human fibroblasts
Highly Cited
1983
Highly Cited
1983
Variation in normal and tumor tissue sensitivity of mice to ionizing radiation-induced DNA strand breaks in vivo.
The efficiency of DNA strand break formation in normal and tumor tissues of mice was measured using the technique of alkaline… 
Highly Cited
1981
Highly Cited
1981
Effects of hyperthermia on repair of radiation-induced DNA strand breaks.
Previous reports have suggested a relationship between the heat-induced changes in nucleoprotein and the hyperthermic enhancement… 
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