DNA Strand Break

A DNA Strand Break involves one or more disruptions of the covalent linkages among phosphodeoxyribose moieties within the sugar-phosphate backbone in… (More)
National Institutes of Health

Papers overview

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2015
2015
In the current model of DNA SSBR, PARP1 is regarded as the sensor of single-strand breaks (SSBs). However, biochemical studies… (More)
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Review
2011
Review
2011
The termini of DNA strand breaks induced by internal and external factors often require processing before missing nucleotides can… (More)
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2007
2007
The involvement of signal transduction in the repair of radiation-induced damage to DNA has been known in eukaryotes but remains… (More)
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Highly Cited
2004
Highly Cited
2004
Ataxia-oculomotor apraxia 1 (AOA1) is an autosomal recessive neurodegenerative disease that is reminiscent of ataxia… (More)
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Highly Cited
2004
Highly Cited
2004
Regulating the topological state of DNA is a vital function of the enzyme DNA topoisomerase I. However, when acting on damaged… (More)
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Highly Cited
2000
Highly Cited
2000
XRCC1 protein is essential for viability in mammals and is required for efficient DNA single-strand break repair and genetic… (More)
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Highly Cited
1999
Highly Cited
1999
The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is an enormous, 470-kDa protein serine/threonine kinase that has… (More)
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Highly Cited
1995
Highly Cited
1995
In situ presence of numerous DNA strand breaks is a typical feature of apoptotic cells. Selective DNA strand break induction by… (More)
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Highly Cited
1992
Highly Cited
1992
The effects of inducible expression of poly(ADP-ribose) polymerase (PADPRP) antisense RNA in HeLa cells were determined in order… (More)
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Highly Cited
1986
Highly Cited
1986
An intimate relationship exists between DNA single-strand breaks, NAD metabolism, and cell viability in quiescent human… (More)
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