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DNA Strand Break

A DNA Strand Break involves one or more disruptions of the covalent linkages among phosphodeoxyribose moieties within the sugar-phosphate backbone in… 
National Institutes of Health

Related topics

Related topics

17 relations
4'-deoxy-4'-iododoxorubicin9-aminocamptothecinBromodeoxyuridineChromosome Structures

Papers overview

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Highly Cited
2013
Highly Cited
2013
Validation of freezing tissues and cells for analysis of DNA strand break levels by comet assay
The comet analysis of DNA strand break levels in tissues and cells has become a common method of screening for genotoxicity. The… 
Highly Cited
2010
Highly Cited
2010
Role for the Mammalian Swi5-Sfr1 Complex in DNA Strand Break Repair through Homologous Recombination
In fission yeast, the Swi5-Sfr1 complex plays an important role in homologous recombination (HR), a pathway crucial for the… 
Highly Cited
2010
Highly Cited
2010
Characterization of a DNA damage‐inducible membrane protein kinase from Deinococcus radiodurans and its role in bacterial radioresistance and DNA strand break repair
Deinococcus radiodurans mutant lacking pyrroloquinoline–quinone (PQQ) synthesis shows sensitivity to γ‐rays and impairment of DNA… 
Review
2007
Review
2007
Targeted cancer therapies based on the inhibition of DNA strand break repair
Both DNA double- and single-strand break repair are highly coordinated processes utilizing signal transduction cascades and post… 
2007
2007
Involvement of a periplasmic protein kinase in DNA strand break repair and homologous recombination in Escherichia coli
The involvement of signal transduction in the repair of radiation‐induced damage to DNA has been known in eukaryotes but remains… 
Highly Cited
2004
Highly Cited
2004
Poly(ADP-ribose) Reactivates Stalled DNA Topoisomerase I and Induces DNA Strand Break Resealing*
Regulating the topological state of DNA is a vital function of the enzyme DNA topoisomerase I. However, when acting on damaged… 
Review
1998
Review
1998
Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication.
Poly(ADP-ribose) polymerase (PARP) is an element of the DNA damage surveillance network evolved by eukaryotic cells to cope with… 
Highly Cited
1995
Highly Cited
1995
Single-step procedure for labeling DNA strand breaks with fluorescein- or BODIPY-conjugated deoxynucleotides: detection of apoptosis and bromodeoxyuridine incorporation.
The methods of in situ labeling of DNA strand breaks have been used to identify apoptotic cells and/or DNA replicating cells… 
Highly Cited
1983
Highly Cited
1983
Variation in normal and tumor tissue sensitivity of mice to ionizing radiation-induced DNA strand breaks in vivo.
The efficiency of DNA strand break formation in normal and tumor tissues of mice was measured using the technique of alkaline… 
Highly Cited
1981
Highly Cited
1981
Effects of hyperthermia on repair of radiation-induced DNA strand breaks.
Previous reports have suggested a relationship between the heat-induced changes in nucleoprotein and the hyperthermic enhancement… 
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