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7-tert-butyldimethylsilyl-10-hydroxycamptothecin

Known as: 1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)- dione, 11-((1,1-dimethylethyl)dimethylsilyl)-4-ethyl-4,9- dihydroxy-, (4S)-, 7-t-butyldimethylsilyl-10-hydroxycamptothecin 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

CamptothecinOrganosilicon Compounds

Narrower (1)

DB-67
analogs & derivatives

Papers overview

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2006
2006
Molecular dynamics simulations and experimental studies of binding and mobility of 7-tert-butyldimethylsilyl-10-hydroxycamptothecin and its 20(S)-4-aminobutyrate ester in DMPC membranes.
The enhanced permeability and retention of liposomes in solid tumors makes liposomal formulations attractive for the targeting of… 
2004
2004
The effect of DB-67, a lipophilic camptothecin derivative, on topoisomerase I levels in non-small-cell lung cancer cells
PurposeTo determine the in vitro drug sensitivity of two non-small-cell lung cancer cell lines after treatment with the novel… 
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