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Potent cytotoxicity of the phosphatase inhibitor microcystin LR and microcystin analogues in OATP1B1- and OATP1B3-expressing HeLa cells
TLDR
These studies show that microcystin-induced phosphatase inhibition results in potent cytotoxicity when micro Cystin compounds can gain intracellular access and are a potent novel class of therapeutic agents for tumors expressing these uptake proteins.
Transporter Gene Expression in Lactating and Nonlactating Human Mammary Epithelial Cells Using Real-Time Reverse Transcription-Polymerase Chain Reaction
TLDR
Data imply CNT3 may play a specialized role in nucleoside accumulation in milk and may identify an important role for PEPT2 and OATP-A transporters at the lactating mammary epithelium.
Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells.
Our laboratory has previously reported the isolation of a murine cDNA which restores reduced folate carrier (RFC) activity and methotrexate (MTX) sensitivity to a MTX-resistant, transport-deficient
Loss of heterozygosity of the human cytosolic glutathione peroxidase I gene in lung cancer.
TLDR
A polymerase chain reaction-based assay demonstrated the existence of three GPX1 alleles characterized by the number of alanines in a polyalanine coding sequence in exon 1, and sequence analysis revealed that they encode structurally different hGPx1 subunits.
Chemo brain (chemo fog) as a potential side effect of doxorubicin administration: role of cytokine-induced, oxidative/nitrosative stress in cognitive dysfunction.
TLDR
Doxorubicin is a chemotherapeutic agent that is commonly administered to breast cancer patients in standard chemotherapy regimens and might affect biochemical processes in a manner that might lead to, or contribute to, chemotherapy-induced cognitive deficits when administered either alone or in combination with other agents.
Human rRNA gene clusters are recombinational hotspots in cancer.
TLDR
It is found that over half of the adult solid tumors show detectable rDNA rearrangements relative to either surrounding nontumor tissue or normal peripheral blood, which makes rDNA restructuring one of the most common chromosomal alterations in adultsolid tumors, illustrates the dynamic plasticity of the human genome.
Multidrug resistance in cells transfected with human genes encoding a variant P-glycoprotein and glutathione S-transferase-pi.
The nucleotide sequence of the mdr1 gene encoding a putative drug efflux pump (P-glycoprotein) is homologous to a class of bacterial membrane-associated transport proteins. These bacterial proteins
A pilot study of pi-class glutathione S-transferase expression in breast cancer: correlation with estrogen receptor expression and prognosis in node-negative breast cancer.
TLDR
GST pi expression is inversely related to hormone receptor status in breast cancer, and this pilot study suggests that increased GST pi expression may be an important predictor of early recurrence and death in node-negative breast cancer patients that merits additional investigation.
Successful Treatment of Inflammatory Myofibroblastic Tumor With Malignant Transformation by Surgical Resection and Chemotherapy
TLDR
The case of a 7-year-old boy with an abdominal mass diagnosed as IMT with malignant transformation is presented, representing successful combined surgery and chemotherapy in the treatment of malignant IMT.
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