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Doxorubicin and paclitaxel-loaded lipid-based nanoparticles overcome multidrug resistance by inhibiting P-glycoprotein and depleting ATP.
TLDR
Enhanced uptake and prolonged retention of doxorubicin were observed with nanoparticle-based formulations in P-gp-overexpressing cells, and injection of pegylated paclitaxel nanoparticles showed marked anticancer efficacy in nude mice bearing resistant NCI/ADR-RES tumors versus all control groups. Expand
Sunitinib malate for the treatment of metastatic renal cell carcinoma and gastrointestinal stromal tumors.
TLDR
Sunitinib is a multiple tyrosine kinase receptor inhibitor approved for the treatment of mRCC and GIST and has anti-tumor activity in patients with breast cancer, neuroendocrine tumors, and non-small cell lung cancer. Expand
Phase I pharmacokinetic studies evaluating single and multiple doses of oral GW572016, a dual EGFR-ErbB2 inhibitor, in healthy subjects
TLDR
Single and multiple oral doses ofGW572016 were well tolerated in healthy subjects, and resulted in dose-related systemic exposure of GW572016, which was similar between treatment and placebo groups. Expand
Development of new lipid-based paclitaxel nanoparticles using sequential simplex optimization.
TLDR
Cytotoxicity studies in MDA-MB-231 cancer cells showed that both nanoparticles have similar anticancer activities compared to Taxol, and Interestingly, PX BTM nanocapsules could be lyophilized without cryoprotectants and rapidly rehydrated with a complete retention of original physicochemical properties, in vitro release properties, and cytotoxicity profile. Expand
Delayed graft function after renal transplantation.
TLDR
Although there is a close association between DGF and reduced GS, there is no association between these donor factors and GS, and this seeming paradox suggests that unknown variables contribute heavily to early graft outcome. Expand
Vena Cava Filter Retrieval Rates and Factors Associated With Retrieval in a Large US Cohort
TLDR
VCF retrieval increased over the study period but remained suboptimal and was weakly correlated with anticoagulation initiation, and in adjusted time‐to‐event models, increasing age, differing regions, and some comorbidities were associated with poorer retrieval rates. Expand
Pharmacokinetics of Intravenous Levofloxacin Administered at 750 Milligrams in Obese Adults
TLDR
The physiochemical properties of levofloxacin suggest that it is an agent which may exhibit altered pharmacokinetics in obese individuals, and its peak concentrations were comparable to those seen with normal-weight individuals. Expand
Generation of New Landomycins with Altered Saccharide Patterns through Over‐expression of the Glycosyltransferase Gene lanGT3 in the Biosynthetic Gene Cluster of Landomycin A in Streptomyces
TLDR
It was verified that LanGT3 is a D‐olivosyltransferase responsible for the transfer of the fourth sugar required for landomycin A biosynthesis, and showed that gene over‐expression is a powerful method for unbalancing biosynthetic pathways in order to generate new metabolites. Expand
PD‐1 Pathway Inhibitors: Immuno‐Oncology Agents for Restoring Antitumor Immune Responses
TLDR
A basic understanding of the role of PD‐1 in modulating the immune system and their use in the cancer treatment is provided, along with pharmacokinetic and pharmacodynamic data and cost considerations. Expand
The influence of antidiabetic medications on the development and progression of prostate cancer.
TLDR
The use of metformin or TZDs trended toward decreased odds of high-grade tumors and decreased risk of progression, while sulfonylureas and high-dose insulin tended toward an increased odds of High grade tumors and increase therisk of progression compared to non-diabetics. Expand
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