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TNFRSF10A gene

Known as: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY, MEMBER 10A, TRAILR1, DR4 
This gene is involved in cell death signal transduction and apoptosis mediation.
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Cell-surface death receptors such as DR4 and DR5 trigger apoptosis through a death-inducing signaling complex (DISC) that… Expand
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Review
2004
Review
2004
Unlike conventional cancer therapeutics, death receptor ligands trigger tumor cell apoptosis independently of the p53 tumor… Expand
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Highly Cited
2002
Highly Cited
2002
Interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) promote the proliferation of multiple myeloma (MM) cells and… Expand
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Highly Cited
2002
Highly Cited
2002
The importance of Bax for induction of tumor apoptosis through death receptors remains unclear. Here we show that Bax can be… Expand
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Highly Cited
2001
Highly Cited
2001
Decoy receptor 3 (DcR3) is a newly identified soluble protein that binds to CD95 ligand (CD95L) and inhibits its proapoptotic… Expand
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Highly Cited
2000
Highly Cited
2000
ABSTRACT Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) (Apo2 ligand [Apo2L]) is a member of the TNF… Expand
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Highly Cited
1999
Highly Cited
1999
TNF and Fas ligand induce apoptosis in tumor cells; however, their severe toxicity toward normal tissues hampers their… Expand
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Highly Cited
1999
Highly Cited
1999
Activation-induced cell death is a process by which overactivated T cells are eliminated, thus preventing potential autoimmune… Expand
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Highly Cited
1999
Highly Cited
1999
Glioblastoma multiforme is a lethal neoplasm refractory to radiochemotherapy. Although glioma cells undergo apoptosis when… Expand
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Highly Cited
1997
Highly Cited
1997
Apo2 ligand (Apo2L [1], also called TRAIL for tumor necrosis factor (TNF)-related apoptosis-inducing ligand [2]) belongs to the… Expand
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