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The Molecular Interaction of Fas and FAP-1
  • J. Yanagisawa, Motoo Takahashi, +8 authors Takaaki Sato
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 28 March 1997
The results showed that the C-terminal three amino acids of human Fas were necessary and sufficient for its interaction with the third PDZ (GLGF) domain of FAP-1, and the direct cytoplasmic microinjection of this tripeptide resulted in the induction of Fas-mediated apoptosis in a colon cancer cell line that expresses both Fas and FAPS. Expand
Endosialin Protein Expression and Therapeutic Target Potential in Human Solid Tumors: Sarcoma versus Carcinoma
Findings suggest that an anti-endosialin immunotoxin might be a promising therapeutic approach for endosialsialin-positive neoplasia, especially synovial sarcoma, fibrosarcomA, malignant fibrous histiocytoma, liposarcomo, and osteOSarcoma. Expand
Human normal hepatocytes are susceptible to apoptosis signal mediated by both TRAIL-R1 and TRAIL-R2
Results indicate that human normal hepatocytes are susceptible to both TRAIL-R1- and TRAil-R2-mediated apoptosis signal, and are therefore likely to be susceptible to hepatocyte toxicity. Expand
Antitumor activity of a spicamycin derivative, KRN5500, and its active metabolite in tumor cells.
KRN5500 prolonged the survival of P388 leukemia- and B16 melanoma-bearing mice but was marginally effective on colon adenocarcinoma 26 and was ineffective even at 170 microM in inhibition of protein synthesis in rabbit reticulocyte lysates. Expand
Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF
Results indicate that IGF-1 activates the Rho/Rho-kinase pathway via a LARG/IGF-1 receptor complex and thereby regulates cytoskeletal rearrangements. Expand
Endosialin/TEM 1/CD248 is a pericyte marker of embryonic and tumor neovascularization.
The data indicate that endosialin is strongly expressed by pericytes during periods of active angiogenesis during embryonic and tumor development, and anti-endosialIn antibodies may have value in identifying vasculature in malignant tissues. Expand
Predominant antitumor effects by fully human anti-TRAIL-receptor 2 (DR5) monoclonal antibodies in human glioma cells in vitro and in vivo.
Results suggest that DR5 is the predominant TRAIL receptor mediating apoptotic signals in human glioma cells, and sensitivity to anti-DR5 mAbs was determined at least in part by the expression level of c-FLIP(L) and Akt. Expand
Switching constant domains enhances agonist activities of antibodies to a thrombopoietin receptor
We enhanced the activities of two agonist antibodies specific for the thrombopoietin receptor (c-MPL) by switching domains within their constant regions to those of different antibody isotypes. OurExpand
TRAIL-R2 Superoligomerization Induced by Human Monoclonal Agonistic Antibody KMTR2
The results indicate that the strong agonistic activity, such as apoptotic signaling and tumor regression, induced by KM TR2 is attributed to TRAIL-R2 superoligomerization induced by the interdimerization of KMTR2. Expand
Aspartate-based inhibitor of interleukin-1 beta-converting enzyme prevents antitumor agent-induced apoptosis in human myeloid leukemia U937 cells.
Results indicate that ICE or ICE-like proteases inhibited by Z-Asp-CH2-DCB are involved in a common pathway of apoptotic cell death in U937 cells. Expand