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Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy–negative individuals
TLDR
It is shown that the Duffy antigen/chemokine receptor gene (DARC) is composed of a single exon and that most Duffy–negative blacks carry a silent FY*B allele with a single T to C substitution at nucleotide −46.
The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast
TLDR
It is shown here that RhAG and also RhGK, a new human homologue expressed in kidney cells only, function as ammonium transport proteins when expressed in yeast, and specifically complement the growth defect of a yeast mutant deficient in ammonium uptake.
RhBG and RhCG, the putative ammonia transporters, are expressed in the same cells in the distal nephron.
TLDR
RhBG and RhCG are present in a major site of ammonia secretion in the kidney, i.e., the CNT and CD, in agreement with their putative role in ammonium transport.
Comparison of the carbohydrate-binding specificities of seven N-acetyl-D-galactosamine-recognizing lectins.
TLDR
Seven plant lectins, known to be specific for N-acetyl-D-galactosamine-(GalNAc) bearing glycoconjugates, have been compared by the binding of their radiolabelled derivatives to eight well-characterized synthetic oligosaccharides immobilized via a spacer on an inert silica matrix (Synsorb).
Expression of RhCG, a new putative NH(3)/NH(4)(+) transporter, along the rat nephron.
TLDR
The aim of this study was to determine the intrarenal and intracellular location of RhCG in rat kidney and to identify the subpopulation of cells within the collecting duct that apically express the beta1 subunit of the H(+)-ATPase.
Molecular cloning and primary structure of the human blood group RhD polypeptide.
TLDR
The sequence homology between the Cc/Ee and D proteins supports the concept that the genes encoding these polypeptides have evolved by duplication of a common ancestor gene.
RhAG protein of the Rhesus complex is a CO2 channel in the human red cell membrane
TLDR
Rh protein, presumably the Rh‐associated glycoprotein RhAG, possesses a gas channel that allows passage of CO2 in addition to NH3.— Endeward, V., Cartron, J.‐P.
Evidence that the red cell skeleton protein 4.2 interacts with the Rh membrane complex member CD47.
TLDR
The results suggest that human protein 4.2, through interaction with CD47, is involved in the skeleton linkage and/or membrane translocation of the Rh complex, however, these potential role(s) of protein4.2 might be not conserved across species.
Genetic basis of the RhD-positive and RhD-negative blood group polymorphism as determined by Southern analysis
TLDR
It is shown that the Rh locus carried by the genome of RhD-positive individuals is composed of two different but strongly related genes of identical general organization whether they expressed the C or c and E or e antigens, and, surprisingly, even when they do not express these epitopes.
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