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TNF receptor-associated factor 5

Known as: TNF Receptor Associated Protein 5, TNF Receptor Associated Factor 5, TNF Receptor-Associated Factor 5 [Chemical/Ingredient] 
A signal transducing tumor necrosis factor receptor associated factor that mediates signaling from CD27 ANTIGENS; CD40 ANTIGENS; and the LYMPHOTOXIN… Expand
National Institutes of Health

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11 relations

Broader (1)

Carrier Proteins
In BloodProcess of secretionTNF receptor-associated factor 4TRAF5 gene
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Papers overview

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Highly Cited
2009
Highly Cited
2009
Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL), the most common form of lymphoma in adulthood, comprises multiple biologically and… Expand
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Highly Cited
2006
Highly Cited
2006
Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif.
Upon recognition of viral infection, RIG-I and Helicard recruit a newly identified adapter termed Cardif, which induces type I… Expand
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2004
2004
TNF receptor-associated factor 5 limits the induction of Th2 immune responses.
The TNF receptor-associated factor (TRAF) family of molecules acts as adapter proteins for signaling pathways initiated by… Expand
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Highly Cited
2003
Highly Cited
2003
TNF-related weak inducer of apoptosis receptor, a TNF receptor superfamily member, activates NF-kappa B through TNF receptor-associated factors.
TNF-related weak inducer of apoptosis (TWEAK) is a member of the TNF ligand family that induces angiogenesis in vivo. The TWEAK… Expand
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Highly Cited
2003
Highly Cited
2003
NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death.
NF-kappaB downregulates tumor necrosis factor (TNF)-induced c-Jun N-terminal kinase (JNK) activation that promotes cell death… Expand
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Review
2001
Review
2001
Tumor necrosis factor receptor-associated factors (TRAFs)
Tumor necrosis factor receptor-associated factors (TRAFS) were initially discovered as adaptor proteins that couple the tumor… Expand
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Highly Cited
1999
Highly Cited
1999
Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif.
Various members of the tumor necrosis factor (TNF) receptor superfamily activate nuclear factor kappaB (NF-kappaB) and the c-Jun… Expand
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Highly Cited
1998
Highly Cited
1998
Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N…
Various members of the tumor necrosis factor (TNF) receptor superfamily interact directly with signaling molecules of the TNF… Expand
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Highly Cited
1998
Highly Cited
1998
RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.
Through specific interactions with members of the tumor necrosis receptor (TNFR) family, adapter molecules such as the serine… Expand
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Highly Cited
1996
Highly Cited
1996
Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region.
CD40 signalings play crucial roles in B-cell function. To identify molecules which transduce CD40 signalings, we have utilized… Expand
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