FLASH coordinates NF-kappa B activity via TRAF2.

  title={FLASH coordinates NF-kappa B activity via TRAF2.},
  author={Yongdoo Choi and Kyung Bo Kim and Hyung Hoi Kim and Ga Sze Hong and Yunhee Kim Kwon and Christopher W. Chung and Young Mi Park and Z J Shen and Bong Jo Kim and Soo Young Lee and Yong Keun Jung},
  journal={The Journal of biological chemistry},
  volume={276 27},
FLASH is a protein recently shown to interact with the death effector domain of caspase-8 and is likely to be a component of the death-inducing signaling complex in receptor-mediated apoptosis. Here we show that antisense oligonucleotide-induced inhibition of FLASH expression abolished TNF-alpha-induced activation of NF-kappaB in HEK293 cells, as determined by luciferase reporter gene expression driven by a NF-kappaB responsive promoter. Conversely, overexpression of FLASH dose-dependently… CONTINUE READING


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