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The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria
TLDR
Members of the Omp85 protein family are found in eukaryotes ranging from plants to humans and are essential for cell viability in yeast and conditional omp85 mutants have defects that arise from compromised insertion of integral proteins. Expand
Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.
TLDR
It is demonstrated that activation of the cell death-inducing ripoptosome platform and RIP3 can generate bioactive IL-1β and implicate them as additional targets for the treatment of pathological IL- 1-driven inflammatory responses. Expand
Molecular architecture and function of the Omp85 family of proteins
TLDR
Aspects of the ancestry and molecular architecture of the Omp85 family of proteins are providing insight into the mechanism by which proteins might be integrated and assembled into bacterial outer membranes. Expand
TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis
TLDR
Results show that TRAF2 has anti-apoptotic signaling roles in addition to promoting NF-κB signaling and that efficient activation of NF-σB by TNFR1 requires the recruitment of cIAP1/2 by TRAf2. Expand
RIPK1 is not essential for TNFR1-induced activation of NF-κB
TLDR
Comparisons between wild type and RIPK1−/− mouse embryonic fibroblasts treated with TNF/IAP antagonist-induced death indicate that models proposing thatRIPK1 is essential for TNFR1 to activate canonical NF-κB are incorrect. Expand
Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane.
TLDR
It is proposed that the precursor form of DIABLO/Smac enters the mitochondria through a stop-transfer pathway and is processed to its active form by the inner membrane peptidase (IMP) complex. Expand
In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8*
TLDR
The pro-survival effect of RIPK1 is mediated by stabilization of TRAF2 and cIAP1, which resulted in processing of p100 NF-κB2 to p52, a decrease in levels of cFLIPL, and activation of caspase-8, culminating in cell death. Expand
Integral membrane proteins in the mitochondrial outer membrane of Saccharomyces cerevisiae
TLDR
Hydropathy predictions together with data from limited protease digestion show three α‐helical transmembrane segments in Om14, which provides functions derived after the endosymbiotic event, and require the translocase in the outer mitochondrial membrane complex for insertion into the outer membrane. Expand
Direct production of proteins with N-terminal cysteine for site-specific conjugation.
TLDR
The ability to directly produce proteins with N-terminal cysteine should simplify the application of native chemical ligation technology to recombinant proteins and make the technique more amenable to researchers with limited expertise in protein chemistry. Expand
Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space.
TLDR
It is shown that no "Tim12" family of proteins exist, but rather that variant forms of the cognate small TIMs have been recently duplicated and modified to provide new functions: the yeast Tim12 is a modified form of Tim10, whereas in humans and some protists variant formsof Tim9, Tim8, and Tim13 are found instead. Expand
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