Skip to search formSkip to main contentSkip to account menu

TIMP3 protein, human

Known as: tissue inhibitor of metalloproteinases-3, human, Mig-5 protein, human, Tissue Inhibitor of Metalloproteinases 3 
Metalloproteinase inhibitor 3 (221aa, ~24 kDa) is encoded by the human TIMP3 gene. This protein is involved in metalloproteinase inhibition.
National Institutes of Health

Related topics

Related topics

11 relations
Angiogenesis Inhibitory ProteinAngiogenic ProcessExtracellular MatrixGenes, Regulator

Broader (2)

Protease InhibitorsTissue Inhibitor of Metalloproteinase-3

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
LRP1 Controls TNF Release via the TIMP-3/ADAM17 Axis in Endotoxin-Activated Macrophages
The metalloproteinase ADAM17 plays a pivotal role in initiating inflammation by releasing TNF from its precursor. Prolonged TNF… 
2014
2014
Tissue inhibitor of metalloproteinase-1 and -3 improves cardiac function in an ischemic cardiomyopathy model rat.
Matrix metalloproteinases (MMPs) and a family of tissue inhibitors of metalloproteinases (TIMPs) may contribute to myocardial… 
2010
2010
TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool.
Regulating transition of hematopoietic stem cells (HSCs) between quiescent and cycling states is critical for maintaining… 
2007
2007
Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system.
OBJECTIVE The major proteases responsible for aggrecan turnover in articular cartilage are the aggrecanases (ADAMTS-4 and ADAMTS… 
2004
2004
Transforming growth factor Beta1 induction of tissue inhibitor of metalloproteinases 3 in articular chondrocytes is mediated by reactive oxygen species.
Transforming growth factor beta1 (TGF-beta1) stimulates cartilage extracellular matrix synthesis but, in excess, evokes synovial… 
2003
2003
Negative impact of tissue inhibitor of metalloproteinase-3 null mutation on lung structure and function in response to sepsis.
Matrix metalloproteinases (MMPs) are degradative enzymes, which act to remodel tissue. Their activity is regulated by the tissue… 
2001
2001
Inhibition of ADAMTS 4 ( aggrecanase-1 ) by tissue inhibitors of metalloproteinases ( TIMP-1 , 2 , 3 and 4 )
ADAMTS4 (aggrecanase-1) is considered to play a key role in the degradation of aggrecan in arthritides. The inhibitory activity… 
Highly Cited
1998
Highly Cited
1998
Human myeloma cells shed the interleukin‐6 receptor: inhibition by tissue inhibitor of metalloproteinase‐3 and a hydroxamate‐based metalloproteinase inhibitor
Interleukin‐6 (IL‐6) is the major growth factor for human myeloma cells, exerting its effect through the IL‐6 receptor (IL‐6R). A… 
1996
1996
Sorsby Fundus Dystrophy: A Family With the Ser181Cys Mutation of the Tissue Inhibitor of Metalloproteinases 3
Sorsby fundusdystrophy (SFD) is an autosomal dominant disorder that is characterized by bilateral loss of central vision… 
Highly Cited
1984
Highly Cited
1984
Effect of K+ depolarization on the synthesis of prostaglandins and hydroxyeicosatetra(5,8,11,14)enoic acids (HETE) in the rat retina. Evidence for esterification of 12-HETE in lipids.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)