Tissue inhibitor of metalloproteinase-1 and -3 improves cardiac function in an ischemic cardiomyopathy model rat.

@article{Uchinaka2014TissueIO,
  title={Tissue inhibitor of metalloproteinase-1 and -3 improves cardiac function in an ischemic cardiomyopathy model rat.},
  author={A. Uchinaka and N. Kawaguchi and S. Mori and Y. Hamada and S. Miyagawa and A. Saito and Y. Sawa and N. Matsuura},
  journal={Tissue engineering. Part A},
  year={2014},
  volume={20 21-22},
  pages={
          3073-84
        }
}
Matrix metalloproteinases (MMPs) and a family of tissue inhibitors of metalloproteinases (TIMPs) may contribute to myocardial remodeling in heart failure. TIMPs are the main inhibitors of MMPs and have other MMP-independent functions. Because little is known of the role of TIMPs in the heart, we examined the effects of TIMPs on cardiac fibroblasts (CFs) and cardiomyocytes. In vitro, TIMP-1-4 enhanced smooth muscle actin (SMA) expression in CFs, and TIMP-1 and TIMP-3 enhanced the expression of… Expand
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  • A. Uchinaka, Kanako Tasaka, +11 authors N. Kawaguchi
  • Medicine
  • European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • 2017
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