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THRA wt Allele

Known as: THRA2, Thyroid Hormone Receptor Alpha Gene, ERBA1 
Human THRA wild-type allele is located in the vicinity of 17q11.2 and is approximately 31 kb in length. This allele, which encodes thyroid hormone… 
National Institutes of Health

Related topics

Related topics

15 relations
17q11.2-q12Biologic DevelopmentCell Differentiation processCell Proliferation

Broader (1)

THRA gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Thyroid Cancer Susceptibility and THRA1 and BAT-40 Repeats Polymorphisms
Although genetic and environmental factors have been identified in the etiology of thyroid cancer, the specific genetic… 
2002
2002
A targeted thyroid hormone receptor alpha gene dominant-negative mutation (P398H) selectively impairs gene expression in differentiated embryonic stem cells.
Thyroid hormone and retinoic acid (RA) are essential for normal neural development in vivo, yet all in vitro differentiation… 
2002
2002
Expansion of microsatellite in the thyroid hormone receptor-alpha1 gene linked to increased receptor expression and less aggressive thyroid cancer.
PURPOSE The purpose of this study was to determine whether the length of the THRA1 microsatellite, which resides in a noncoding… 
Highly Cited
2001
Highly Cited
2001
Suppression of the deafness and thyroid dysfunction in Thrb-null mice by an independent mutation in the Thra thyroid hormone receptor alpha gene.
Deletion of thyroid hormone receptor beta (TR beta), a ligand-dependent transcription factor encoded by the Thrb gene, causes… 
1997
1997
Microsatellite instability and loss of heterozygosity in primary breast tumours.
Allelic imbalance or loss of heterozygosity (LOH) studies have been used extensively to identify regions on chromosomes that may… 
1996
1996
Allele loss of tumour suppressor genes on chromosome 17 in human testicular germ cell tumours.
The molecular genetics of testicular germ cell tumours (TGCT) are still largely unknown. We investigated 20 TGCT tumours for… 
1995
1995
Five distinct deleted regions on chromosome 17 defining different subsets of human primary breast tumors.
In this study, we analyzed 105 paired sporadic primary breast tumor and normal tissue samples for loss of heterozygosity (LOH) on… 
Highly Cited
1993
Highly Cited
1993
THRA1 and D17S183 flank an interval of < 4 cM for the breast-ovarian cancer gene (BRCA1) on chromosome 17q21.
In order to pinpoint the locale of the gene for early-onset familial breast and ovarian cancer (BRCA1), polymorphisms were… 
1993
1993
A somatic cell hybrid map of the long arm of human chromosome 17, containing the familial breast cancer locus (BRCA1).
We describe a detailed somatic cell hybrid map of human chromosome 17q11.2-q23, containing the familial breast and ovarian cancer… 
1992
1992
Developmental expression of mRNAs from a rat C-erbA genomic locus.
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