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THRA gene

Known as: Genes, TR-alpha, THRA Genes, ERBA-RELATED 7 
This gene plays a role in receptor signaling and regulation of transcription. It is involved in thyroid hormone binding.
National Institutes of Health

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Related topics

15 relations
Biologic DevelopmentCell Differentiation processCell ProliferationHomeostasis

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THRA wt Allele

Papers overview

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Review
2015
Review
2015
Melatonin feedback on clock genes: a theory involving the proteasome
The expression of ‘clock’ genes occurs in all tissues, but especially in the suprachiasmatic nuclei (SCN) of the hypothalamus… 
Highly Cited
2015
Highly Cited
2015
Thyroid hormone resistance syndrome due to mutations in the thyroid hormone receptor α gene (THRA)
Background Resistance to thyroid hormone is characterised by a lack of response of peripheral tissues to the active form of… 
Highly Cited
2013
Highly Cited
2013
An adult female with resistance to thyroid hormone mediated by defective thyroid hormone receptor α.
CONTEXT The first human cases (female, age 6 y; father and daughter, ages 47 and 11 y, respectively) with growth retardation… 
Highly Cited
2004
Highly Cited
2004
Tissue-specific mRNA expression profiles of human nuclear receptor subfamilies.
Pairs of forward and reverse primers and TaqMan probes specific to each human nuclear receptor were prepared. Analysis of the… 
Highly Cited
2002
Highly Cited
2002
Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer
The relation between thyroid status and diseases and cancer is unclear. No detailed analysis of thyroid hormone receptor (TR… 
Highly Cited
2000
Highly Cited
2000
Cloning and Characterization of Two Novel Thyroid Hormone Receptor β Isoforms
ABSTRACT Thyroid hormone (T3) activates nuclear receptor transcription factors, encoded by the TRα (NR1A1) and TRβ (NR1A2) genes… 
Highly Cited
1997
Highly Cited
1997
Inhibition of Peroxisome Proliferator Signaling Pathways by Thyroid Hormone Receptor
Peroxisome proliferators (e.g. clofibric acid) and thyroid hormone play an important role in the metabolism of lipids. These… 
Highly Cited
1993
Highly Cited
1993
Induction of Rev-ErbA alpha, an orphan receptor encoded on the opposite strand of the alpha-thyroid hormone receptor gene, during adipocyte differentiation.
Rev-ErbA alpha (Rev-Erb) is a nuclear hormone receptor-related transcriptional activator that is encoded on the noncoding strand… 
Highly Cited
1993
Highly Cited
1993
The orphan receptor Rev-ErbA alpha activates transcription via a novel response element
Rev-ErbA alpha (Rev-Erb) is a nuclear hormone receptor-related protein encoded on the opposite strand of the alpha-thyroid… 
Highly Cited
1990
Highly Cited
1990
Differential and tissue-specific regulation of the multiple rat c-erbA messenger RNA species by thyroid hormone.
Thyroid hormone (T3) has been shown to regulate the level of its receptor in a number of tissues and cell lines. Recently… 
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