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Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event
TLDR
Evidence is shown that the novel coronavirus (2019-nCov) is not-mosaic consisting in almost half of its genome of a distinct lineage within the betacoronavirus, suggesting that the hypothesis that 2019-nCoV has originated from bats is very likely. Expand
Recruitment of Herpes Simplex Virus Type 1 Transcriptional Regulatory Protein ICP4 into Foci Juxtaposed to ND10 in Live, Infected Cells
TLDR
It is proposed that a proportion of the ND10-associated I CP4 foci represent ICP4 molecules being recruited onto parental viral genomes, a process likely to be a critical step early in lytic infection, suggesting a principle common to the alpha- and betaherpesviruses. Expand
Prevalence of human herpes virus types 1-7 in the semen of men attending an infertility clinic and correlation with semen parameters.
TLDR
The DNA of herpes viruses is frequently detected in the semen of asymptomatic fertile and infertile male patients and a statistical significance between leukocytospermia and the presence of EBV DNA was observed. Expand
Formation of Nuclear Foci of the Herpes Simplex Virus Type 1 Regulatory Protein ICP4 at Early Times of Infection: Localization, Dynamics, Recruitment of ICP27, and Evidence for the De Novo Induction
TLDR
Examination of developing plaques or thinly seeded cells infected at high multiplicity found evidence to suggest that at least some of the ND10-viral nucleoprotein complex association could be attributed to de novo formation ofND10-like structures in response to incoming viral genomes. Expand
Visualization of parental HSV‐1 genomes and replication compartments in association with ND10 in live infected cells
TLDR
Systems to visualize parental and replicated herpes simplex virus type 1 (HSV‐1) amplicon genomes in association with PML nuclear bodies (ND10) in live cells provide a novel insight into virus–ND10 interactions and provide compelling visualization of their functional relevance. Expand
Differential expression and mutation of the ras family genes in human breast cancer.
TLDR
The findings indicate that the aberrant expression of ras genes may be an initial event in breast cancer oncogenesis and that K-ras point mutations are rarely involved in the development of mammary neoplasias. Expand
p53 codon 72 polymorphism and its association with bladder cancer.
TLDR
Evidence is provided that this p53 polymorphism is implicated in bladder carcinogenesis and that individuals harboring the Arg/Arg genotype have an increased risk of developing bladder cancer. Expand
Evaluation of Parvo B19, CMV and HPV viruses in human aborted material using the polymerase chain reaction technique.
TLDR
This study of 102 cases of spontaneous abortion does not implicate CMV and HPV in the aetiopathogenesis of spontaneous abortions, although it indicates a possible abortional role for Parvo B19 virus. Expand
Detection of Herpes Simplex Virus and Human Papilloma Virus in Ophthalmic Pterygium
TLDR
The correlation of postoperative recurrence and a history of conjunctivitis with the simultaneous detection of HPV and HSV, implies a possible viral cooperation affecting the clinical profile of pterygium, and supports the concept that pteryGium can be considered a neoplastic condition. Expand
The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY
TLDR
Evidence is presented for an Akt1-dependent pathway that controls interferon (IFN)-regulated gene expression and antiviral immunity and contributes to the full activation of ISGs by relieving their repression by EMSY and BRCA2. Expand
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