• Publications
  • Influence
2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum.
BACKGROUND Thyroid disease in pregnancy is a common clinical problem. Since the guidelines for the management of these disorders by the American Thyroid Association (ATA) were first published inExpand
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Thyroid hormone regulation of metabolism.
Thyroid hormone (TH) is required for normal development as well as regulating metabolism in the adult. The thyroid hormone receptor (TR) isoforms, α and β, are differentially expressed in tissues andExpand
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Mechanisms of thyroid hormone action.
  • G. Brent
  • Biology, Medicine
  • The Journal of clinical investigation
  • 4 September 2012
Our understanding of thyroid hormone action has been substantially altered by recent clinical observations of thyroid signaling defects in syndromes of hormone resistance and in a broad range ofExpand
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Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation
PKD1 is the most common site for mutations in human autosomal dominant polycystic kidney disease (ADPKD). ADPKD is characterized by progressive replacement of kidney tissue by epithelial cysts andExpand
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Clinical practice. Graves' disease.
  • G. Brent
  • Medicine
  • The New England journal of medicine
  • 2008
Copyright © 2008 Massachusetts Medical Society. A 23-year-old woman presents with palpitations. Over the past 6 months, she has reported loose stools, a 10-lb (4.5-kg) weight loss despite a goodExpand
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Thyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specific.
In newborns and small mammals, cold-induced adaptive (or nonshivering) thermogenesis is produced primarily in brown adipose tissue (BAT). Heat production is stimulated by the sympathetic nervousExpand
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The molecular basis of thyroid hormone action.
  • G. Brent
  • Biology, Medicine
  • The New England journal of medicine
  • 29 September 1994
Progress has been made in understanding the molecular basis of a number of clinical manifestations of thyroid disease, yet many questions remain. Why are there two thyroid hormone-receptor genes? IsExpand
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Retinoic acid induces sodium/iodide symporter gene expression and radioiodide uptake in the MCF-7 breast cancer cell line.
The sodium/iodide symporter (NIS) stimulates iodide uptake in normal lactating breast, but is not known to be active in nonlactating breast or breast cancer. We studied NIS gene regulation and iodideExpand
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Environmental exposures and autoimmune thyroid disease.
  • G. Brent
  • Medicine
  • Thyroid : official journal of the American…
  • 6 July 2010
BACKGROUND Environmental exposures, ranging from perchlorate in rocket fuel to polychlorinated biphenols, have been shown to influence thyroid function. Although most of these agents are associatedExpand
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Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor.
We have isolated a c-erbA cDNA clone from a GH3 cell library. The clone, denoted erb62, is 4.5 kilobases long and encodes a 461-amino acid beta-type c-erbA protein. This c-erbA protein bindsExpand
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