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International Society for Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation.
TLDR
It is suggested that the prevalence of premature ejaculation is considerably lower than previously thought and that ongoing research will lead to a more complete understanding of the pathophysiology as well as new efficacious and safe treatments for this sexual dysfunction.
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An Evidence-Based Unified Definition of Lifelong and Acquired Premature Ejaculation: Report of the Second International Society for Sexual Medicine Ad Hoc Committee for the Definition of Premature…
TLDR
The ISSM unified definition of lifelong and acquired PE represents the first evidence-based definition for these conditions and will enable researchers to design methodologically rigorous studies to improve the understanding of acquired PE.
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Thyroid hormone and male gonadal function.
TLDR
The potential of thyroid hormone in the modulation of male reproductive functions was not determined for several years because of the apparent clinical irrelevance of signs and symptoms related to male gonadal function compared with the systemic effects of hyper- and hypothyroidism.
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An Update of the International Society of Sexual Medicine's Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE)
TLDR
An update of the International Society of Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation (PE) and best practices treatment recommendations are presented to guide clinicians, both familiar and unfamiliar with PE, in facilitating treatment of their patients.
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Development and validation of a 6-item version of the female sexual function index (FSFI) as a diagnostic tool for female sexual dysfunction.
TLDR
The abridged FSFI-6 is a novel tool that can help any doctor to disclose FSD rapidly and efficiently and is a valuable tool for screening women that are likely to suffer from FSD.
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Retinoic acid X receptor in the diploblast, Tripedalia cystophora.
TLDR
It is shown by cDNA and gene cloning that a Cnidarian, Tripedalia cystophora, possesses a retinoid receptor (jRXR) with remarkable homology to vertebrate retinoic acid X receptors (RXRs), suggesting that RXR is an early component of the regulatory mechanisms of metazoa.
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Repression of kit Expression by Plzf in Germ Cells
TLDR
It is shown that Plzf directly represses the transcription of kit, a hallmark of spermatogonial differentiation, which is likely due to the deregulated expression of genes controlling the switch between sperMatogonial self-renewal and differentiation.
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Sperm recovery and ICSI outcomes in Klinefelter syndrome: a systematic review and meta-analysis
TLDR
The present data suggest that performing TESE/micro-TESE in subjects with KS results in SRRs of close to 50%, and then PRs and LBRs of close-to 50%, with the results being independent of any clinical or biochemical parameters tested.
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Opposing effects of retinoic acid and FGF9 on Nanos2 expression and meiotic entry of mouse germ cells
TLDR
It is shown that Nanos2 is continuously expressed in male germ cells from fetal gonocytes to postnatal spermatogonial stem cells and that NANOS2 interacts with PUM2, and that these two proteins colocalize in the ribonucleoparticle and polysomal fractions on sucrose gradients, supporting the notion that they bind RNA.
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Disorders of orgasm and ejaculation in men.
TLDR
The recommendations concerning state-of-the-art knowledge of disorders of orgasm and ejaculation represent the opinion of seven experts from seven countries developed in a process over a 2-year period.
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