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The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress
It is reported that BRCA1 is modified by small ubiquitin-like modifier (SUMO) in response to genotoxic stress, and co-localizes at sites of DNA damage with SUMO1, SUMO2/3 and the SUMO-conjugating enzyme Ubc9.
PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia.
PIC1 is the first identified NB-associated protein that interacts with PML, the function of which may lead to a fuller understanding of the molecular events leading to APL.
Assessment of Minimal Residual Disease in Standard-Risk AML.
Although mutations associated with preleukemic clones remained detectable during ongoing remission after chemotherapy, NPM1 mutations were detected in 69 of 70 patients at the time of relapse and provided a better marker of disease status.
Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia.
Characterization of PML revealed that it is a putative zinc finger protein and potential transcription factor that is commonly expressed, with at least three major transcription products.
SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation.
It is shown that SUMO-1 covalently modifies PML both in vivo and in vitro and that the modification is mediated either directly or indirectly by the interaction of UBC9 with PML through the RING finger domain and the modifications are dependant on the correct subcellular compartmentalisation of target proteins.
Localization of the gene for familial adenomatous polyposis on chromosome 5
It is shown that the FAP gene is on chromosome 5, most probably near bands 5q21–q22, and that the same gene may be involved in both familial and non-familial cases of a given tumour.
Presenting white blood cell count and kinetics of molecular remission predict prognosis in acute promyelocytic leukemia treated with all-trans retinoic acid: result of the Randomized MRC Trial.
All-trans retinoic acid (ATRA) is an essential component of the treatment of acute promyelocytic leukemia, but the optimal timing and duration remain to be determined and a positive RT-PCR after consolidation identifies patients at a higher risk of relapse.
Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Français de Cytogénétique Hématologique, Groupe de Français…
This study highlights the importance of combining morphologic, cytogenetic, and molecular analyses for optimal management of APL patients and better understanding of the pathogenesis of the disease.
The molecular pathogenesis of acute promyelocytic leukaemia: implications for the clinical management of the disease.
BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair.
An immunohistochemical approach is used to demonstrate that BRCA1 directed ligation of ubiquitin occurs during S-phase and in response to replication stress and DNA damage and is therefore likely to be a significant aspect of B RCA1 cellular activity.