TDP1 gene

Known as: SCAN1, TYROSYL-DNA PHOSPHODIESTERASE 1, FLJ11090 
This gene plays a role in the repair of both single and double strand breaks in DNA.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2018
05101519982018

Papers overview

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2014
2014
Poly(ADP-ribose) polymerases (PARP) attach poly(ADP-ribose) (PAR) chains to various proteins including themselves and chromatin… (More)
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Highly Cited
2012
Highly Cited
2012
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) repairs topoisomerase I cleavage complexes (Top1cc) by hydrolyzing their 3'-phosphotyrosyl… (More)
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2010
2010
Human tyrosyl-DNA phosphodiesterase (TDP1) hydrolyzes the phosphodiester bond at a DNA 3'-end linked to a tyrosyl moiety and has… (More)
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2009
2009
Human tyrosyl-DNA phosphodiesterase (TDP1) hydrolyzes the phosphodiester bond at a DNA 3' end linked to a tyrosyl moiety. This… (More)
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Highly Cited
2006
Highly Cited
2006
Agents targeting topoisomerases are active against a wide range of human tumors. Stabilization of covalent complexes, converting… (More)
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2005
Highly Cited
2005
Tyrosyl-DNA phosphodiesterase (Tdp1) catalyzes the hydrolysis of the tyrosyl-3' phosphate linkage found in topoisomerase I-DNA… (More)
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Highly Cited
2005
Highly Cited
2005
Tyrosyl-DNA phosphodiesterase (TDP1) is a DNA repair enzyme that removes peptide fragments linked through tyrosine to the 3' end… (More)
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2004
2004
Tyrosyl DNA phosphodiesterase 1 (TDP1) is a repair enzyme that removes adducts, e.g. of topoisomerase I from the 3'-phosphate of… (More)
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Highly Cited
2002
Highly Cited
2002
Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs covalently bound topoisomerase I–DNA complexes and is essential for preventing the… (More)
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Highly Cited
2002
Highly Cited
2002
When a replication fork collides with a DNA topoisomerase I (Top1) cleavage complex, the covalently bound enzyme must be removed… (More)
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