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TDP1 gene

Known as: SCAN1, TYROSYL-DNA PHOSPHODIESTERASE 1, FLJ11090 
This gene plays a role in the repair of both single and double strand breaks in DNA.
National Institutes of Health

Related topics

Related topics

8 relations
DNA RepairDouble Strand Break RepairHydrolysisSPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE, WITH AXONAL NEUROPATHY

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TDP1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors
2014
2014
Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.
2014
2014
Cellular and biochemical analyses of TDP1 mediated chromosomal break repair
Tyrosyl DNA phosphodiesterase 1 (TDP1) is an end- rocessing enzyme involved in the repair of abortive topoisomerase I (Top1… 
2013
2013
Abstract 2194: Tyrosyl DNA phosphodiesterase I is a prognostic factor and its inhibition synergizes response to topoisomerase poisons in malignant glioma.
Malignant Glioma is the most common type of primary brain tumors in adults accounting for about 80% of all gliomas. Despite the… 
2013
2013
Role of Tyrosyl-DNA Phosphodiesterase I (TDP1) as a Prognostic and Predictive Factor in Malignant Glioma
Al-Keilani MS, Agarwal S, Alqudah MA, Sibenaller Z, Ryken TC, and Assem M. Tyrosyl DNA Phosphodiesterase I (TDP1): A Promising… 
2012
2012
Table 2. [Selected TDP1 Pathogenic Variants].
2011
2011
Investigation of the role of the NLP and TDP1 chromatin associated proteins in transcription control in Trypanosoma brucei
2010
2010
A tyrosyl DNA phosphodiesterase 1 from kinetoplastid parasite Leishmania donovani (LdTdp1) capable of removing topo I–DNA covalent complexes
Tyrosyl DNA phosphodiesterase 1 (Tdp1) is a member of phospholipase D superfamily, which cleaves a broad range of 3′‐DNA adducts… 
Review
2008
Review
2008
Irinotecan Pharmacogenetics : Influence of PharmacodynamicGenes
Purpose: Irinotecan is an important drug for the treatment of solid tumors. Although genes involved in irinotecan… 
Review
2006
Review
2006
[Molecular genetics of inherited neuropathies].
To clarify the specific features and molecular mechanisms of five diseases that we previously reported, we reviewed recent… 
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