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TDP1 gene

Known as: SCAN1, TYROSYL-DNA PHOSPHODIESTERASE 1, FLJ11090 
This gene plays a role in the repair of both single and double strand breaks in DNA.
National Institutes of Health

Papers overview

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Review
2014
Review
2014
TDP1 and TDP2 were discovered and named based on the fact they process 3'- and 5'-DNA ends by excising irreversible protein… Expand
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Highly Cited
2010
Highly Cited
2010
Human tyrosyl-DNA phosphodiesterase (TDP1) hydrolyzes the phosphodiester bond at a DNA 3′-end linked to a tyrosyl moiety and has… Expand
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Highly Cited
2009
Highly Cited
2009
Human tyrosyl-DNA phosphodiesterase (TDP1) hydrolyzes the phosphodiester bond at a DNA 3' end linked to a tyrosyl moiety. This… Expand
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Highly Cited
2007
Highly Cited
2007
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) cleaves the phosphodiester bond between a covalently stalled topoisomerase I (Topo I) and… Expand
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Highly Cited
2006
Highly Cited
2006
Agents targeting topoisomerases are active against a wide range of human tumors. Stabilization of covalent complexes, converting… Expand
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Highly Cited
2005
Highly Cited
2005
Human tyrosyl-DNA phosphodiesterase (Tdp1) hydrolyzes the phosphodiester bond between a DNA 3′ end and a tyrosyl moiety. In… Expand
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Highly Cited
2005
Highly Cited
2005
Tyrosyl-DNA phosphodiesterase (Tdp1) catalyzes the hydrolysis of the tyrosyl-3' phosphate linkage found in topoisomerase I-DNA… Expand
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Highly Cited
2004
Highly Cited
2004
Tyrosyl DNA phosphodiesterase 1 (TDP1) is a repair enzyme that removes adducts, e.g. of topoisomerase I from the 3′-phosphate of… Expand
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Highly Cited
2002
Highly Cited
2002
Accidental or drug-induced interruption of the breakage and reunion cycle of eukaryotic topoisomerase I (Top1) yields complexes… Expand
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Highly Cited
2002
Highly Cited
2002
When a replication fork collides with a DNA topoisomerase I (Top1) cleavage complex, the covalently bound enzyme must be removed… Expand
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