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TDP1 wt Allele

Known as: FLJ11090, SCAN1, Tyrosyl-DNA Phosphodiesterase 1 wt Allele 
Human TDP1 wild-type allele is located in the vicinity of 14q32.11 and is approximately 90 kb in length. This allele, which encodes tyrosyl-DNA… 
National Institutes of Health

Related topics

Related topics

7 relations
DNA RepairDouble Strand Break RepairHydrolysisSPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE, WITH AXONAL NEUROPATHY

Broader (1)

TDP1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis
2009
2009
In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation.
Review
2008
Review
2008
Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy.
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a recently discovered enzyme that catalyzes the hydrolysis of 3'-phosphotyrosyl bonds… 
Review
2007
Review
2007
DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1
Highly Cited
2006
Highly Cited
2006
Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes.
Review
2006
Review
2006
TDP1-dependent DNA single-strand break repair and neurodegeneration.
DNA single-strand breaks (SSBs) are the commonest DNA lesions that arise spontaneously in living cells. Cells employ efficient… 
Highly Cited
2005
Highly Cited
2005
Deficiency in 3′-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)
Tyrosyl-DNA phosphodiesterase (TDP1) is a DNA repair enzyme that removes peptide fragments linked through tyrosine to the 3′ end… 
2004
2004
glaikit Is Essential for the Formation of Epithelial Polarity and Neuronal Development
Review
2003
Review
2003
DNA Single-Strand Break Repair and Spinocerebellar Ataxia
Highly Cited
2002
Highly Cited
2002
Mutation of TDP1, encoding a topoisomerase I–dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy
Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs covalently bound topoisomerase I–DNA complexes and is essential for preventing the… 
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