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TCF7L2 wt Allele

Known as: TCF-4, TCF4, Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) wt Allele 
Human TCF7L2 wild-type allele is located in the vicinity of 10q25.3 and is approximately 217 kb in length. This allele, which encodes transcription… 
National Institutes of Health

Related topics

Related topics

12 relations
10q25.3Homo sapiensMelanogenesis PathwayNegative Regulation of Apoptosis

Broader (1)

TCF7L2 gene

Papers overview

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Highly Cited
2012
Highly Cited
2012
Pitt-Hopkins syndrome-associated mutations in TCF4 lead to variable impairment of the transcription factor function ranging from hypomorphic to dominant-negative effects.
Transcription factor TCF4 (alias ITF2, SEF2 or E2-2) is a broadly expressed basic helix-loop-helix (bHLH) protein that functions… 
Highly Cited
2012
Highly Cited
2012
Role of (cid:1) -Catenin and TCF/LEF Family Members in Transcriptional Activity of HIV in Astrocytes
The Wnt/ (cid:1) -catenin pathway is involved in diverse cell functions governing development and disease. (cid:1) -Catenin, a… 
Highly Cited
2011
Highly Cited
2011
Replication of the TCF4 intronic variant in late-onset Fuchs corneal dystrophy and evidence of independence from the FCD2 locus.
PURPOSE Fuchs corneal dystrophy (FCD) is an autosomal dominant disease of the corneal endothelium with variable penetrance and… 
Highly Cited
2010
Highly Cited
2010
Cognitive and Sensorimotor Gating Impairments in Transgenic Mice Overexpressing the Schizophrenia Susceptibility Gene Tcf4 in the Brain
Highly Cited
2009
Highly Cited
2009
Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer
PurposeColorectal cancer is one of the most common cancers worldwide. We tested the hypothesis that differences in the expression… 
Highly Cited
2009
Highly Cited
2009
A Wnt-kinase network alters nuclear localization of TCF-1 in colon cancer
Constitutive activation of the Wnt/β-catenin pathway has been implicated as the primary cause of colon cancer. However, the major… 
Highly Cited
2007
Highly Cited
2007
TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors.
Highly Cited
2007
Highly Cited
2007
The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4.
Ileal Crohn's disease (CD), a chronic mucosal inflammation, is characterized by two pertinent features: a specific decrease of… 
Highly Cited
2002
Highly Cited
2002
Fibroblast Growth Factor-2 Induces Lef/Tcf-dependent Transcription in Human Endothelial Cells*
Lef/Tcf proteins belong to a family of architectural transcription factors that control developmental processes and play an… 
Highly Cited
2002
Highly Cited
2002
Identification of membrane-type matrix metalloproteinase-1 as a target of the β-catenin/Tcf4 complex in human colorectal cancers
Genetic alterations of APC and CTNNB1 (β-catenin) have been identified in a number of human cancers including tumors arising in… 
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