β-Catenin and Plakoglobin N- and C-tails Determine Ligand Specificity*

@article{Solanas2004CateninAP,
  title={$\beta$-Catenin and Plakoglobin N- and C-tails Determine Ligand Specificity*},
  author={Guiomar Solanas and Susana Miravet and David Casagolda and Julio Casta{\~n}o and Imma Raurell and Ana Corrionero and Antonio Garcı́a de Herreros and Mireia Du{\~n}ach},
  journal={Journal of Biological Chemistry},
  year={2004},
  volume={279},
  pages={49849 - 49856}
}
β-Catenin and plakoglobin are related proteins involved in the regulation of adherens junctions and desmosomes. Moreover, by binding to Tcf-4, they can act as transcriptional modulators of genes involved in embryonic development and tumorigenesis. However, they associate to distinct Tcf-4 subdomains causing opposing effects on Tcf-4 binding to DNA: whereas β-catenin does not affect this binding, plakoglobin prevents it. Both proteins are composed by two N- and C-tails and a central armadillo… 

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