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TAN 67

Known as: TAN-67 
 
National Institutes of Health

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2 relations

Broader (2)

AnalgesicsQuinolines

Papers overview

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2002
2002
Delta opioid agonists and volatile anesthetics facilitate cardioprotection via potentiation of K(ATP) channel opening.
Opioids and volatile anesthetics produce marked cardioprotective effects against myocardial infarction via the activation of ATP… Expand
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Highly Cited
2001
Highly Cited
2001
Differential activation of extracellular signal regulated kinase isoforms in preconditioning and opioid-induced cardioprotection.
Stimulation of the delta(1)-opioid receptor has been shown to trigger ischemic preconditioning (IPC). Additionally, myocardial… Expand
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Highly Cited
2001
Highly Cited
2001
ERK and p38 MAP kinase activation are components of opioid-induced delayed cardioprotection
Abstract Opioids have been previously shown to confer acute and delayed cardioprotection against a prolonged ischemic insult. We… Expand
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Highly Cited
2001
Highly Cited
2001
Stress-activated protein kinase phosphorylation during cardioprotection in the ischemic myocardium.
Stress-activated protein kinases may be essential to cardioprotection. We assessed the role of p38 in an in vivo rat model of… Expand
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Highly Cited
2001
Highly Cited
2001
Essential activation of PKC-delta in opioid-initiated cardioprotection.
Stimulation of the delta(1)-opioid receptor confers cardioprotection to the ischemic myocardium. We examined the role of protein… Expand
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Highly Cited
2000
Highly Cited
2000
Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels.
We examined the role of the sarcolemmal and mitochondrial ATP-sensitive potassium (K(ATP)) channel in a rat model of myocardial… Expand
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Highly Cited
1999
Highly Cited
1999
Opioid-induced second window of cardioprotection: potential role of mitochondrial KATP channels.
Opioids have been previously shown to confer short-term cardioprotection against a prolonged ischemic insult. Therefore, the… Expand
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Highly Cited
1998
Highly Cited
1998
TAN-67, a δ1-opioid receptor agonist, reduces infarct size via activation of Gi/o proteins and KATP channels.
We have previously shown that delta (δ)-opioid receptors, most notably δ1, are involved in the cardioprotective effect of… Expand
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1998
1998
TAN-67, a delta 1-opioid receptor agonist, reduces infarct size via activation of Gi/o proteins and KATP channels.
We have previously shown that delta (delta)-opioid receptors, most notably delta 1, are involved in the cardioprotective effect… Expand
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1998
1998
Rational drug design and synthesis of a highly selective nonpeptide delta-opioid agonist, (4aS*,12aR*)-4a-(3-hydroxyphenyl)-2-methyl- 1,2,3,4,4a,5,12,12a-octahydropyrido[3,4-b]acridine (TAN-67).
We designed highly selective non-peptide agonists for the delta-opioid receptor. On the basis of the "message-address" concept in… Expand
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