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Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord
Summary Menthol and other counterstimuli relieve itch, resulting in an antipruritic state that persists for minutes to hours. However, the neural basis for this effect is unclear, and the underlying… Expand
Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents.
- A. Saitoh, Y. Kimura, T. Suzuki, K. Kawai, H. Nagase, J. Kamei
- Journal of pharmacological sciences
In the present study, we investigated the antidepressant- and anxiolytic-like effects of (+)-4-[(aR)-a-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC80), a… Expand
The role of mu- and kappa-opioid receptors in cocaine-induced conditioned place preference.
- T. Suzuki, Y. Shiozaki, Y. Masukawa, M. Misawa, H. Nagase
- Medicine, Chemistry
- Japanese journal of pharmacology
Effects of buprenorphine, U-50,488H, naltrexone and lithium chloride on cocaine conditioned place preference were examined. Buprenorphine, a mixed opioid agonist-antagonist, blocked the… Expand
In silico design of novel probes for the atypical opioid receptor MRGPRX2
The primate-exclusive MRGPRX2 G protein-coupled receptor (GPCR) has been suggested to modulate pain and itch. Despite putative peptide and small molecule MRGPRX2 agonists, selective nanomolar potency… Expand
TAN-67, a δ1-opioid receptor agonist, reduces infarct size via activation of Gi/o proteins and KATP channels.
- J. E. Schultz, A. Hsu, H. Nagase, G. Gross
- Medicine, Biology
- American journal of physiology. Heart and…
- 1 March 1998
We have previously shown that delta (δ)-opioid receptors, most notably δ1, are involved in the cardioprotective effect of ischemic preconditioning (PC) in rats; however, the mechanism by which… Expand
Differential antinociceptive effects of endomorphin-1 and endomorphin-2 in the mouse.
- L. Tseng, M. Narita, +4 authors J. Kampine
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 February 2000
Two highly selective mu-opioid receptor agonists, endomorphin-1 and endomorphin-2, have been identified and postulated to be endogenous mu-opioid receptor ligands. We determined the antinociceptive… Expand
Blockade of morphine reward through the activation of kappa-opioid receptors in mice.
The effects of systemic (s.c.) treatment with the kappa-agonists U-50,488H and E-2078 (a stable dynorphin analog) on the morphine-induced place preference were examined in mice. Morphine (s.c.)… Expand
Different roles of μ-, δ- and κ-opioid receptors in ethanol-associated place preference in rats exposed to conditioned fear stress
The present study was designed to investigate the role of the endogenous opioid system in the development of ethanol-induced place preference in rats exposed to conditioned fear stress (exposure to… Expand
Antinociceptive effects of the selective non-peptidic delta-opioid receptor agonist TAN-67 in diabetic mice.
- J. Kamei, A. Saitoh, +4 authors Y. Kasuya
- Chemistry, Medicine
- European journal of pharmacology
- 24 March 1995
The antinociceptive potencies of 2-methyl-4 alpha alpha-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12 alpha alpha-octahydro-quinolino[2,3,3-g]isoquinoline (TAN-67), a non-peptidic delta-opioid receptor… Expand
Potent antinociceptive effects of TRK-820, a novel κ-opioid receptor agonist
Abstract TRK-820, a new type of 4,5-epoxymorphinan derivative, was investigated in vivo for antinociceptive activities and its selectivity on various opioid receptors in mice. Trk-820 given s.c. or… Expand