H. Nagase

Publications543
h-index49
Citations9,917
Highly Influential Citations333
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Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents.
TLDR
It is possible that delta-opioid-receptor agonists might be novel and potent antidepressants that also have anxiolytic-like effects and may play an important role in the regulation of emotional responses.
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The role of mu- and kappa-opioid receptors in cocaine-induced conditioned place preference.
TLDR
Results suggest that mu- and kappa-opioid receptors may be involved in cocaine-induced conditioned place preference and that the antagonism of cocaine- induced place preference by U-50,488H or naltrexone does not result from a functional antagonism.
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In silico design of novel probes for the atypical opioid receptor MRGPRX2
TLDR
MRGPRX2 is a unique atypical opioid-like receptor important for modulating mast cell degranulation, which can now be specifically modulated with ZINC-3573, which represents a potent MRG PRX2-selective agonist, showing little activity against 315 other GPCRs and 97 representative kinases.
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Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels.
TLDR
The data suggest that delta(1)-opioid receptor stimulation is cardioprotective against myocardial ischemia and sublethal arrhythmias and suggest a role for the mitochondrial K(ATP) channel in mediating these cardioprotsective effects.
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TAN-67, a δ1-opioid receptor agonist, reduces infarct size via activation of Gi/o proteins and KATP channels.
TLDR
These results are the first to suggest that stimulating the δ1-opioid receptor elicits a cardioprotective effect that is mediated via Gi/o proteins and KATP channels in the intact rat heart.
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The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions
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Differential antinociceptive effects of endomorphin-1 and endomorphin-2 in the mouse.
TLDR
It is proposed that endomorphin-1 produces antinociception by stimulating one type of mu-opioid receptor, whereas endomorphicin-2 initially stimulates different mu-OPioid receptors, which subsequently induce the release of dynorphins that act on kappa-opIOid receptors to produce antinOCiception.
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Opioid-induced second window of cardioprotection: potential role of mitochondrial KATP channels.
TLDR
The results suggest that delta1-opioid receptor stimulation, 24 to 48 hours before an ischemic insult, produces a delayed cardioprotective effect that is possibly the result of mitochondrial KATP channel activation.
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Different roles of μ-, δ- and κ-opioid receptors in ethanol-associated place preference in rats exposed to conditioned fear stress
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Antinociceptive effects of the selective non-peptidic delta-opioid receptor agonist TAN-67 in diabetic mice.
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