H. Nagase

Publications425
h-index44
Citations7,309
Highly Influential Citations264
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • T. Suzuki
  • 638 Publications, 16,015 Citations
  • H. Fujii
  • 172 Publications, 2,354 Citations
  • P. Portoghese
  • 505 Publications, 17,818 Citations
  • J. Kamei
  • 361 Publications, 5,627 Citations
  • Publications
  • Influence
Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord
Summary Menthol and other counterstimuli relieve itch, resulting in an antipruritic state that persists for minutes to hours. However, the neural basis for this effect is unclear, and the underlying… Expand
  • 195
  • 15
  • PDF
Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents.
In the present study, we investigated the antidepressant- and anxiolytic-like effects of (+)-4-[(aR)-a-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC80), a… Expand
  • 152
  • 11
  • PDF
The role of mu- and kappa-opioid receptors in cocaine-induced conditioned place preference.
Effects of buprenorphine, U-50,488H, naltrexone and lithium chloride on cocaine conditioned place preference were examined. Buprenorphine, a mixed opioid agonist-antagonist, blocked the… Expand
  • 146
  • 10
In silico design of novel probes for the atypical opioid receptor MRGPRX2
The primate-exclusive MRGPRX2 G protein-coupled receptor (GPCR) has been suggested to modulate pain and itch. Despite putative peptide and small molecule MRGPRX2 agonists, selective nanomolar potency… Expand
  • 92
  • 8
  • PDF
TAN-67, a δ1-opioid receptor agonist, reduces infarct size via activation of Gi/o proteins and KATP channels.
We have previously shown that delta (δ)-opioid receptors, most notably δ1, are involved in the cardioprotective effect of ischemic preconditioning (PC) in rats; however, the mechanism by which… Expand
  • 115
  • 7
Differential antinociceptive effects of endomorphin-1 and endomorphin-2 in the mouse.
Two highly selective mu-opioid receptor agonists, endomorphin-1 and endomorphin-2, have been identified and postulated to be endogenous mu-opioid receptor ligands. We determined the antinociceptive… Expand
  • 139
  • 6
  • PDF
Blockade of morphine reward through the activation of kappa-opioid receptors in mice.
The effects of systemic (s.c.) treatment with the kappa-agonists U-50,488H and E-2078 (a stable dynorphin analog) on the morphine-induced place preference were examined in mice. Morphine (s.c.)… Expand
  • 70
  • 6
Different roles of μ-, δ- and κ-opioid receptors in ethanol-associated place preference in rats exposed to conditioned fear stress
The present study was designed to investigate the role of the endogenous opioid system in the development of ethanol-induced place preference in rats exposed to conditioned fear stress (exposure to… Expand
  • 76
  • 5
Antinociceptive effects of the selective non-peptidic delta-opioid receptor agonist TAN-67 in diabetic mice.
The antinociceptive potencies of 2-methyl-4 alpha alpha-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12 alpha alpha-octahydro-quinolino[2,3,3-g]isoquinoline (TAN-67), a non-peptidic delta-opioid receptor… Expand
  • 55
  • 5
Potent antinociceptive effects of TRK-820, a novel κ-opioid receptor agonist
Abstract TRK-820, a new type of 4,5-epoxymorphinan derivative, was investigated in vivo for antinociceptive activities and its selectivity on various opioid receptors in mice. Trk-820 given s.c. or… Expand
  • 66
  • 5