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Cocaine-Induced Intracellular Signaling and Gene Expression Are Oppositely Regulated by the Dopamine D1 and D3 Receptors
TLDR
It is suggested that the D1 and D3 receptors elicit opposite regulation of target gene expression by regulating ERK activation and c-fos induction after acute and chronic cocaine treatment. Expand
Hypoxia‐enhanced wound‐healing function of adipose‐derived stem cells: Increase in stem cell proliferation and up‐regulation of VEGF and bFGF
TLDR
Results suggest that hypoxia increases the proliferation of ADSC and enhances the wound‐healing function of ADSCs, at least partly, by up‐regulating the secretion of VEGF and bFGF. Expand
Current research on opioid receptor function.
TLDR
The main purpose of this article is to review the recent work done on opioids and their receptor functions to provide an informative reference for better understanding the opioid system and further elucidation of the opioid receptor function from a physiological and pharmacological point of view. Expand
Mechanisms underlying hypoxia-induced neuronal apoptosis
TLDR
The known mechanisms underlying apoptosis in neurons exposed to Hypoxia and hypoxia-ischemia are examined and it is suggested that the balance in the expression of pro- and anti-apoptotic genes that likely determines the fate of neurons exposure to hypoxIA may also account for the regional differences in vulnerability to hypoxic insults. Expand
Rapid Hypoxia Preconditioning Protects Cortical Neurons From Glutamate Toxicity Through δ-Opioid Receptor
TLDR
DOR is involved in neuroprotection induced by rapid HPC in cortical neurons, and prolonged hypoxia caused severe neuronal injury with a significant decrease in DADLE binding density and DOR mRNA level. Expand
Neuroprotective role of delta-opioid receptors in cortical neurons.
TLDR
Testing the effect of opioid receptor activation and inhibition on cultured cortical neurons in hypoxia suggests that DOR plays a crucial role in neuroprotection in normoxic and hypoxic environments. Expand
Ontogeny and distribution of opioid receptors in the rat brainstem
TLDR
The distribution and postnatal ontogeny of opioid receptors have been investigated using in vitro quantitative receptor autoradiography and it is concluded that the brainstem is essentially a mu-receptor region through delta-receptors are present. Expand
Neuroprotective role of δ-opioid receptors in cortical neurons
TLDR
It is demonstrated that δ-opioid receptor (DOR) activation protects cortical neurons against glutamate-induced injury and hypothetically states that glutamate is a mediator of hypoxic injury in neurons. Expand
Oxygen-sensitive {delta}-opioid receptor-regulated survival and death signals: novel insights into neuronal preconditioning and protection.
TLDR
It is shown that the delta-opioid receptor (DOR), an oxygen-sensitive membrane protein, mediates the HPC protection through specific signaling pathways, and demonstrates a novel mechanism of HPC neuroprotection (i.e. the intracellular up-regulation of DOR-regulated survival signals). Expand
δ‐, but not µ‐, opioid receptor stabilizes K+ homeostasis by reducing Ca2+ influx in the cortex during acute hypoxia
Past work has shown that δ‐opioid receptor (DOR) activation by [D‐Ala2,D‐Leu5]‐enkephalin (DADLE) attenuated the disruption of K+ homeostasis induced by hypoxia or oxygen‐glucose deprivation (OGD) inExpand
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