Skip to search formSkip to main contentSkip to account menu
Direct Involvement of Orexinergic Systems in the Activation of the Mesolimbic Dopamine Pathway and Related Behaviors Induced by Morphine
TLDR
Findings provide new evidence that orexin-containing neurons in the VTA are directly implicated in the rewarding effect and hyperlocomotion induced by morphine through activation of the mesolimbic dopamine pathway in rodents.
View on Publisher
Chronic Pain Induces Anxiety with Concomitant Changes in Opioidergic Function in the Amygdala
TLDR
The present data constitute the first evidence that chronic pain has an anxiogenic effect in mice and may be associated with changes in opioidergic function in the amygdala.
View on Nature
Direct Evidence of Astrocytic Modulation in the Development of Rewarding Effects Induced by Drugs of Abuse
TLDR
Direct evidence is provided that astrocytes may, at least in part, contribute to the synaptic plasticity induced by drugs of abuse during the development of rewarding effects induced by psychostimulants and opioids.
View on Springer
Direct evidence for the involvement of brain‐derived neurotrophic factor in the development of a neuropathic pain‐like state in mice
TLDR
It is demonstrated here for the first time that the increase in intracellular Ca2+ concentration by application of BDNF in cultured mouse spinal neurons was abolished by pre‐treatment with either K‐252a or Ro‐32‐0432.
View on Wiley
Implication of protein kinase C in the orexin‐induced elevation of extracellular dopamine levels and its rewarding effect
In the present study, we investigated the role of orexinergic systems in the activation of midbrain dopamine neurons. In an in vitro study, exposure to either orexin A or orexin B under superfusion…
View on Wiley
Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension.
  • T. Nagaoka, K. Fagan, M. Oka
  • Medicine, Biology
    American journal of respiratory and critical care…
  • 1 March 2005
TLDR
Results suggested that inhaled Y-27632 was more effective than inhaled nitric oxide as a selective pulmonary vasodilator in hypoxic PH, and that Rho kinase-mediated vasoconstriction was also involved in the other models of PH.
View on PubMed
Neuropathic and chronic pain stimuli downregulate central mu-opioid and dopaminergic transmission.
View on PubMed
Hippocampal epigenetic modification at the brain‐derived neurotrophic factor gene induced by an enriched environment
TLDR
It is suggested that an enriched environment increases BDNF mRNA expression via sustained epigenetic modification in the mouse hippocampus via sustained methylases and demethylases in the hippocampus.
View on Wiley
Different roles of μ-, δ- and κ-opioid receptors in ethanol-associated place preference in rats exposed to conditioned fear stress
View via Publisher
Chronic pain‐induced emotional dysfunction is associated with astrogliosis due to cortical δ‐opioid receptor dysfunction
TLDR
It is shown that mice with chronic pain exhibit anxiety‐like behavior and an increase of astrocytes in the cingulate cortex due to the dysfunction of cortical δ‐opioid receptor systems, which may lead to emotional disorders including aggravated anxiety under chronic pain‐like state.
View on Wiley
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License