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TACR1 gene

Known as: TACR1, SUBSTANCE P RECEPTOR, SPR 
This gene plays a regulatory role in phosphatidylinositol metabolism of substance P.
National Institutes of Health

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Related topics

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G Protein-Coupled Receptor SignalingLigand BindingReceptor SignalingSignal Transduction

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TACR1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Raised arterial blood pressure in neurokinin‐1 receptor‐deficient mice (NK1R−/−): evidence for a neural rather than a vascular mechanism
What is the central question of this study? Does genetic ablation of neurokinin‐1 receptors alter arterial blood pressure? What… 
2016
2016
Truncated neurokinin-1 receptor is an ubiquitous antitumor target in hepatoblastoma, and its expression is independent of tumor biology and stage.
The substance P (SP; also known as TAC1)/neurokinin-1 receptor (NK1R; also known as TACR1) complex is a critical part in the… 
2016
2016
Perseveration by NK1R-/- (‘knockout’) mice is blunted by doses of methylphenidate that affect neither other aspects of their cognitive performance nor the behaviour of wild-type mice in the 5-Choice…
The underlying cause(s) of abnormalities expressed by patients with attention deficit hyperactivity disorder (ADHD) have yet to… 
2012
2012
Differential mRNA expression of TACR1 after ischemic peritoneal trauma: a pilot animal study
PurposeExperimental trial in an in vivo animal model in the laboratory facilities of a university department of obstetrics and… 
Review
2008
Review
2008
Tachykinin receptors and gastrointestinal motility: focus on humans.
Peptides of the tachykinin (TK) family were first discovered in the gastrointestinal tissue about 75 years ago and supposed to be… 
2007
2007
Bladder inflammatory transcriptome in response to tachykinins: Neurokinin 1 receptor-dependent genes and transcription regulatory elements
BackgroundTachykinins (TK), such as substance P, and their neurokinin receptors which are ubiquitously expressed in the human… 
2004
2004
Fine mapping of the 2p11 dyslexia locus and exclusion of TACR1 as a candidate gene
Developmental dyslexia, or reading disability, is a multigenic complex disease for which at least five loci, i.e. DYX1–3 and DYX5… 
2004
2004
Fine Mapping and SNP Analysis of Positional Candidates at the Preeclampsia Susceptibility Locus (PREG1) on Chromosome 2
Genome scans in Icelandic, Australian and New Zealand, and Finnish families have localized putative susceptibility loci for… 
2004
2004
Phenotypic and genetic analyses of subcongenic BB.SHR rat lines shorten the region on chromosome 4 bearing gene(s) for underlying facets of metabolic syndrome.
Congenic BB.SHR (D4Got41-Npy-Tacr1; BB.4S) rats develop an incomplete metabolic syndrome with obesity, hyperleptinemia, and… 
Highly Cited
2000
Highly Cited
2000
NK1, NK2 and NK3 tachykinin receptor localization and tachykinin distribution in the ileum of the mouse
Tachykinin receptors NK1r, NK2r and NK3r bind tachykinins with different affinities and share pharmacological and molecular… 
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