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Tachykinins and tachykinin receptors: a growing family.
- J. Pennefather, A. Lecci, M. Candenas, E. Patak, F. Pinto, C. Maggi
- Biology, Medicine
- Life sciences
- 6 February 2004
The biological actions of tachykinins are mediated through three types of receptors denoted NK(1), NK(2) and NK(3) that belong to the family of G protein-coupled receptors. Expand
Involvement of 5-hydroxytryptamine1A receptors in the modulation of micturition reflexes in the anesthetized rat.
- A. Lecci, S. Giuliani, P. Santicioli, C. Maggi
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 July 1992
Intravenous administration of the selective 5-hydroxytryptamine (5-HT)1A receptor agonist 8-hydroxy-2-(di-N-propylaminotetralin (8-OH-DPAT) and of a low doses of buspirone elicited the supraspinal… Expand
Newly discovered tachykinins raise new questions about their peripheral roles and the tachykinin nomenclature.
The tachykinin family has recently been extended by the discovery of a third tachykinin gene encoding previously unknown mammalian tachykinins (hemokinin 1, endokinin A and endokinin B) that have a… Expand
Cyclophosphamide cystitis in rats: involvement of capsaicin-sensitive primary afferents.
- C. Maggi, A. Lecci, P. Santicioli, E. del Bianco, S. Giuliani
- Journal of the autonomic nervous system
- 15 May 1992
It is concluded that CYP-induced cystitis is not accompanied by a toxic effect on bladder nerves and that the decrease in bladder capacity is entirely mediated through stimulation of capsaicin-sensitive afferent fibres, presumably linked to the formation of the irritant metabolite of CYP, acrolein. Expand
Effect of nociceptin on heart rate and blood pressure in anaesthetized rats.
- S. Giuliani, M. Tramontana, A. Lecci, C. Maggi
- European journal of pharmacology
- 27 August 1997
The findings indicate that nociceptin exerts a pronounced depressant effect on cardiovascular function which is produced indirectly through a concomitant inhibition and activation, respectively, of the sympathetic and parasympathetic outflows to the cardiovascular system. Expand
Pharmacology of transmission to gastrointestinal muscle.
Recent evidence obtained using receptor knockout mice have confirmed the involvement of the above-mentioned excitatory transmitters but have revealed an unexpected complexity in the nitrergic transmission, where the effects of NO are manifested only in the presence of carbon monoxide. Expand
Peripheral actions of tachykinins
Preclinical evidence obtained through the use of selective tachykinin receptor antagonists indicates that endogenous tachyKinins are involved in augmented smooth muscle contraction, vasodilatation, chemotaxis and activation of immune cells, mucus secretion, water absorption/secretion. Expand
Tachykinins as modulators of the micturition reflex in the central and peripheral nervous system
The overall available information suggests that TK receptor antagonists may affect bladder motility/reflexes which occur during different pathological states, while having little influence on the normal motor bladder function. Expand
Tachykinins and tachykinin receptors in the gut, with special reference to NK2 receptors in human
The results indicate that, even when there is a significant redundance in the effects of TKs and in the role of their receptors, the selective blockade of tachykinin NK2 receptors can have functional consequences on human intestinal motility and perception, but this can occur without the disruption of the physiological functions. Expand