Skip to search formSkip to main contentSkip to account menu

T-box transcription factor TBX21

Known as: TBX21, T-Box Protein 21, T-Box Expressed In T Cells 
T-box transcription factor TBX21 (535 aa, ~58 kDa) is encoded by the human TBX21 gene. This protein is involved in the regulation of interferon-gamma… 
National Institutes of Health

Related topics

Related topics

9 relations
DNA-Binding ProteinsGenes, RegulatorMigration, CellT-Lymphocyte

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Histone modifications and their role in epigenetics of atopy and allergic diseases
This review covers basic aspects of histone modification and the role of posttranslational histone modifications in the… 
Highly Cited
2015
Highly Cited
2015
Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+ T cells
Significance IL-21 is a type I cytokine important for immune cell differentiation and function. We found that transcription… 
Highly Cited
2013
Highly Cited
2013
Induction of pathogenic Th17 cells by inducible salt sensing kinase SGK1 (P1145)
Th17 cells are highly proinflammatory cells that are critical for clearing extracellular pathogens and induction of multiple… 
Highly Cited
2012
Highly Cited
2012
Distinct requirements for T-bet in gut innate lymphoid cells
The transcription factor T-bet drives the differentiation of NKp46-expressing IL-22–producing innate lymphoid cells 
Highly Cited
2012
Highly Cited
2012
Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans.
Highly Cited
2011
Highly Cited
2011
IL-15 Regulates Homeostasis and Terminal Maturation of NKT Cells
Semi-invariant NKT cells are thymus-derived innate-like lymphocytes that modulate microbial and tumor immunity as well as… 
Highly Cited
2011
Highly Cited
2011
Epigenetic Changes at Il12rb2 and Tbx21 in Relation to Plasticity Behavior of Th17 Cells
Plasticity within Th cell populations may play a role in enabling site-specific immune responses to infections while limiting… 
Highly Cited
2009
Highly Cited
2009
T-bet-Deficient NOD Mice Are Protected from Diabetes Due to Defects in Both T Cell and Innate Immune System Function1
The transcription factor T-bet (Tbx21) is critical for Th1 polarization of CD4+ T cells. Genetic deletion of Tbx21 can cause… 
Highly Cited
2008
Highly Cited
2008
Functional deficit of T regulatory cells in Fulani, an ethnic group with low susceptibility to Plasmodium falciparum malaria
Previous interethnic comparative studies on the susceptibility to malaria performed in West Africa showed that Fulani are more… 
Highly Cited
2004
Highly Cited
2004
TBX21: A functional variant predicts improvement in asthma with the use of inhaled corticosteroids
TBX21 encodes for the transcription factor T-bet (T-box expressed in T cells), which influences naïve T lymphocyte development… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)