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Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice.
TLDR
Results indicate substantial plasticity of Th17 commitment toward a Th1-like profile and suggest a major role of Th1 cells in the induction of disease in this model of type 1 diabetes.
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Immune cell crosstalk in type 1 diabetes
TLDR
This Review focuses on the nature of this crosstalk between the innate and the adaptive immune responses and how pathogens influence the process.
View on Nature
Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes
TLDR
It is shown that soluble extracts of S. mansoni worm or egg completely prevent onset of type 1 diabetes in NOD mice but only if injection is started at 4 weeks of age.
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Validated germline-competent embryonic stem cell lines from nonobese diabetic mice
TLDR
The derivation of NOD ES cell lines capable of generating chimeric mice after stable genetic modification are described, which will enable the dissection of closely linked loci and the role they have in the onset of type 1 diabetes but also facilitate the generation of new transgenics.
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Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic mice
TLDR
Until relatively recently humans might expect to succumb to a variety of infectious agents, the current freedom from infection might permit the expression of a genetic predisposition to autoimmune pathology and be responsible for the increased incidence of IDDM.
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Cyclophosphamide-Induced Type-1 Diabetes in the NOD Mouse Is Associated with a Reduction of CD4+CD25+Foxp3+ Regulatory T Cells1
TLDR
It is concluded that acceleration of T1D by CY is associated with a reduction in CD4+CD25+Foxp3+ Tregs and can be prevented by transfer of CD4-CD25-Tregs, which are implicated as key players in immune tolerance and suppression of antitumor responses.
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Guidelines for the use of flow cytometry and cell sorting in immunological studies
TLDR
It is rare to find an immunological paper or read a conference abstract in which the authors did not use flow cytometry as the main tool to dissect the immune system and identify its fine and complex functions, and recent developments have created the sophisticated technology of mass cytometry.
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Inhibition of Autoimmune Type 1 Diabetes by Gastrointestinal Helminth Infection
TLDR
Protection from diabetes was afforded by helminth infection, appeared to inhibit autoimmune diabetes by disrupting pathways leading to the destruction of beta cells, and was mediated by seemingly independent mechanisms depending on the parasite but which may be to be related to the capacity of the host to mount a Th2 response.
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Immune-potentiating effects of the chemotherapeutic drug cyclophosphamide.
TLDR
Historical and recent data on CTX-mediated immunomodulation are critically evaluated and the resulting implications for immunotherapy are discussed.
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Schistosoma mansoni egg antigens induce Treg that participate in diabetes prevention in NOD mice
TLDR
It is shown that SEA can have a direct effect on CD4+ T cells increasing expression of TGF‐β, integrin β8 and galectins, and these effects of SEA on DC and T cells may act in synergy to induce Foxp3+ Treg in the NOD mouse.
View on Wiley
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