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Src Homology 2 Domain-Containing, Transforming Protein 1

Known as: SHC1 Protein, SHC-Transforming Protein 1, Src Homology 2 Domain Containing Transforming Protein C1 
An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor… 
National Institutes of Health

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In BloodProcess of secretionSHC1 geneagonists

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SHC1 protein, human

Papers overview

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2017
2017
TNFSF15 inhibits VEGF‐stimulated vascular hyperpermeability by inducing VEGFR2 dephosphorylation
Vascular hyperpermeability is critical in ischemic diseases, including stroke and myocardial infarction, as well as in… 
2012
2012
Homology Modeling and Validation of the Human M1 Muscarinic Acetylcholine Receptor
One of the major targets of available drugs on the market is the family of G-protein coupled receptors (GPCR). In practice 14… 
2011
2011
Ligand supported homology modeling and docking evaluation of CCR2: docked pose selection by consensus scoring
Chemokine receptor 2 (CCR2) is a G-protein coupled receptor (GPCR) and a crucial target for various inflammatory and autoimmune… 
2011
2011
Homology modeling in tandem with 3D-QSAR analyses: a computational approach to depict the agonist binding site of the human CB2 receptor.
2010
2010
A computational study on cannabinoid receptors and potent bioactive cannabinoid ligands: homology modeling, docking, de novo drug design and molecular dynamics analysis
When X-ray structure of a ligand-bound receptor is not available, homology models of the protein of interest can be used to… 
Review
2008
Review
2008
Novel structural insights into F-actin-binding and novel functions of calponin homology domains.
Highly Cited
2007
Highly Cited
2007
EHD1 and Eps15 Interact with Phosphatidylinositols via Their Eps15 Homology Domains*
The C-terminal Eps15 homology domain-containing protein, EHD1, regulates the recycling of receptors from the endocytic recycling… 
2005
2005
Phosphorylation of Ser 24 in the Pleckstrin Homology Domain of Insulin Receptor Substrate-1 by Mouse Pelle-like Kinase / Interleukin-1 Receptor-associated Kinase CROSS-TALK BETWEEN INFLAMMATORY…
From the ‡Diabetes Unit, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda… 
2004
2004
Identification and characterization of human DIAPH3 gene in silico.
Formin homology proteins with FH1 and FH2 domains are signaling effectors for assembly and polarization of actin filaments. FH1… 
2001
2001
The Insulin Receptor Substrate (IRS)-1 Pleckstrin Homology Domain Functions in Downstream Signaling*
The pleckstrin homology (PH) domain of the insulin receptor substrate-1 (IRS-1) plays a role in directing this molecule to the… 
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