SHC1 protein, human

Known as: SHC1, SHCA protein, human, SH2 Domain Containing Transforming Protein 1 
Widely expressed as 3 isoforms, p66SHC, p52SHC and p46SHC, by human SHC1 Gene, 583-aa 63-kDa (precursor) cytoplasmic SH2 Domain Containing… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1972-2017
020406019722017

Papers overview

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Highly Cited
2002
Highly Cited
2002
The TrkB receptor tyrosine kinase and its ligand, BDNF, have an essential role in certain forms of synaptic plasticity. However… (More)
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Highly Cited
2000
Highly Cited
2000
The BCR/ABL oncogene causes chronic myelogenous leukemia, a myeloproliferative disorder characterized by clonal expansion of… (More)
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Highly Cited
1999
Highly Cited
1999
Overexpression of both cellular Src (c-Src) and the epidermal growth factor receptor (EGFR) occurs in many of the same human… (More)
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Highly Cited
1999
Highly Cited
1999
The aim of this study is to present a complete scoring system for subjective health complaints (SHC) as they are experienced by… (More)
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Highly Cited
1997
Highly Cited
1997
The epidermal growth factor receptor (EGFR) tyrosine kinase recently was identified as providing a link to mitogen-activated… (More)
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Highly Cited
1995
Highly Cited
1995
Biological function of the BCR-ABL oncogene is dependent on its activated tyrosine kinase. Mutations that inactivate the SRC… (More)
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Highly Cited
1994
Highly Cited
1994
Src homology 2 (SH2) domains provide specificity to intracellular signaling by binding to specific phosphotyrosine (phospho-Tyr… (More)
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Highly Cited
1994
Highly Cited
1994
In response to NGF, the Trk receptor tyrosine kinase forms a complex with SHC, a protein that couples receptor tyrosine kinases… (More)
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Highly Cited
1994
Highly Cited
1994
c-erbB-3 is a member of the type I (EGF receptor-related) family of growth factor receptors for which no ligand has been… (More)
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Highly Cited
1992
Highly Cited
1992
A new SH2-containing sequence, SHC, was isolated by screening cDNA libraries with SH2 representative DNA probes. The SHC cDNA is… (More)
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