Skip to search formSkip to main contentSkip to account menu
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain
TLDR
The cloning and enzymatic characterization of the first specific sn-1 DAG lipases are reported, providing a possible explanation for a fundamental change in endocannabinoid function during brain development.
View on PubMed
Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
TLDR
Results obtained in a panel of tumor cell lines clearly indicate that, of the five natural compounds tested, cannabidiol is the most potent inhibitor of cancer cell growth, with significantly lower potency in noncancer cells.
View on Publisher
Effects of cannabinoids and cannabinoid‐enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes
TLDR
CBD and Δ9‐tetrahydrocannabinol interact with transient receptor potential (TRP) channels and enzymes of the endocannabinoid system to explore its role in Cannabidiol-like properties.
View on Wiley
From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology.
TLDR
This review article aims to describe and critically discuss the pharmacology and potential impact on mammalian physiology of all major phytocannabinoids, and not only of the most famous one Δ(9)-tetrahydrocannabinol, and the adaptive pro-homeostatic physiological, or maladaptive pathological, roles of the ECS in mammalian cells, tissues, and organs.
View on PubMed
Novel selective and metabolically stable inhibitors of anandamide cellular uptake.
View on PubMed
Adolescent exposure to THC in female rats disrupts developmental changes in the prefrontal cortex
View on Elsevier
Possible endocannabinoid control of colorectal cancer growth.
View on PubMed
The endocannabinoid signalling system: Biochemical aspects
View on Elsevier
Non‐THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro‐apoptotic effects and underlying mechanisms
TLDR
Cannabinoid receptor activation induces prostate carcinoma cell apoptosis, but cannabinoids other than Δ9‐tetrahydrocannabinol (THC) have not been investigated, and some of these compounds antagonize transient receptor potential melastatin type‐8 (TRPM8) channels, the expression of which is necessary for androgen receptor (AR)‐dependent PCC survival.
View on Wiley
The levels of the endocannabinoid receptor CB2 and its ligand 2-arachidonoylglycerol are elevated in endometrial carcinoma.
TLDR
The endocannabinoid system seems to play an important role in human endometrial carcinoma, and modulation of CB(2) activity/expression may account for a tumor-suppressive effect.
View on PubMed
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License