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Spermidine/Spermine N1-Acetyltransferase

Known as: spermidine-spermine N(1)-acetyltransferase, spermidine acetyltransferase, cSAT transferase 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (2)

AcetyltransferaseAcyltransferase
SAT1 geneSAT1 wt AlleleSLC26A1 gene

Narrower (2)

SAT1 protein, humanSat2 protein, mouse

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity
In obesity and type 2 diabetes, Glut4 glucose transporter expression is decreased selectively in adipocytes. Adipose-specific… 
Highly Cited
2012
Highly Cited
2012
Structural and inflammatory heterogeneity in subcutaneous adipose tissue: relation with liver histopathology in morbid obesity.
Review
2009
Review
2009
Polyamine catabolism and disease.
In addition to polyamine homoeostasis, it has become increasingly clear that polyamine catabolism can play a dominant role in… 
Highly Cited
2007
Highly Cited
2007
Spermidine/spermine N1-acetyltransferase overexpression in kidney epithelial cells disrupts polyamine homeostasis, leads to DNA damage, and causes G2 arrest.
Expression of spermidine/spermine N(1)-acetyltransferase (SSAT) increases in kidneys subjected to ischemia-reperfusion injury… 
2003
2003
Small interfering RNA suppression of polyamine analog-induced spermidine/spermine n1-acetyltransferase.
N1,N11-diethylnorspermine (DENSPM) is a polyamine analog that down-regulates polyamine biosynthesis and potently upregulates the… 
Highly Cited
2003
Highly Cited
2003
A novel polyamine analog inhibits growth and induces apoptosis in human breast cancer cells.
Polyamine analogs have demonstrated considerable activity against many important solid tumor models including breast cancer… 
Highly Cited
2001
Highly Cited
2001
Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells.
N(1),N(11)-Diethylnorspermine (DENSPM) is a polyamine analogue with clinicalrelevance as an experimental anticancer agent and the… 
Highly Cited
2001
Highly Cited
2001
Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation.
Spermidine/spermine N(1)-acetyltransferase (SSAT), a key enzyme in mammalian polyamine catabolism, undergoes rapid turnover (half… 
Highly Cited
1998
Highly Cited
1998
The Identification of a Cis-element and a Trans-acting Factor Involved in the Response to Polyamines and Polyamine Analogues in the Regulation of the Human Spermidine/Spermine N 1-Acetyltransferase…
The superinduction of spermidine/spermineN 1-acetyltransferase (SSAT) gene has been associated with a cytotoxic response to a new… 
Highly Cited
1994
Highly Cited
1994
Properties and structure of spermidine acetyltransferase in Escherichia coli.
Spermidine acetyltransferase (SAT) from Escherichia coli was purified about 40,000-fold. The molecular mass of native SAT was 95… 
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