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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.
TLDR
The use of MSP is demonstrated to identify promoter region hypermethylation changes associated with transcriptional inactivation in four important tumor suppressor genes (p16, p15, E-cadherin and von Hippel-Lindau) in human cancer.
Cabozantinib in progressive medullary thyroid cancer.
TLDR
Cabozantinib (140 mg per day) achieved a statistically significant improvement of PFS in patients with progressive metastatic MTC and represents an important new treatment option for patients with this rare disease.
An achaete-scute homologue essential for neuroendocrine differentiation in the lung
TLDR
It is shown that human achaete-scute homologue-–1 (hASH1) is selectively expressed in normal fetal pulmonary neuro endocrine cells, as well as in the diverse range of lung cancers with neuroendocrine features, and strikingly, newborn mice bearing a disruption of the ASH1 gene have no detectable pulmonary Neuroendocrine cells.
p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3
TLDR
Identification of HIC-1 (hypermethylated in cancer), a new zinc-finger transcription factor gene which is ubiquitously expressed in normal tissues, but underexpressed in different tumour cells where it is hypermethylated, is led to.
Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression.
TLDR
Evidence is provided that the protein hairy-enhancer-of-split-1 (HES-1) acts in a similar manner as its Drosophila homolog, hairy, to transcriptionally repress achaete-scute expression, indicating a key part of the process that determines neural fate in Dosophila is conserved in human lung cancer cells.
Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer.
TLDR
It is suggested that a broad range of SCLC cells has tumorigenic capacity rather than a small discrete population, and intrinsic tumor cell heterogeneity, including variation in key regulatory factors such as ASCL1, can modulate tumorigenicity in S CLC.
RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas
TLDR
Overexpression of RREB-1 protein in TT cells confers the ability to mediate increased transactivation of the CT gene promoter-reporter construct during Ras- or Raf-induced differentiation, suggesting that RREb-1 may play a role in Ras and Raf signal transduction in medullary thyroid cancer and other cells.
Notch signaling induces cell cycle arrest in small cell lung cancer cells.
TLDR
Notch activation, in the setting of a highly proliferative hASH1-dependent NE neoplasm, can be associated with growth arrest and apparent reduction in neoplastic potential, suggesting that the previously described function of Notch proteins as proto-oncogenes is highly context-dependent.
Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130
TLDR
Constutive activation of STAT3 in HNSCC may use an autocrine/paracrine-activating loop mediated by IL6 and other cytokines acting through the gp130 receptor family, which may confer both proliferative and survival potential in this malignancy.
Notch Signaling Induces Rapid Degradation of Achaete-Scute Homolog 1
TLDR
It is reported that in addition to its known transcriptional mechanism, Notch signaling also leads to rapid degradation of the basic helix-loop-helix (bHLH) transcription factor human achaete-scute homolog 1 (hASH1).
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