Polyamine catabolism and disease.

@article{Casero2009PolyamineCA,
  title={Polyamine catabolism and disease.},
  author={Robert Anthony Casero and Anthony E. Pegg},
  journal={The Biochemical journal},
  year={2009},
  volume={421 3},
  pages={323-38}
}
In addition to polyamine homoeostasis, it has become increasingly clear that polyamine catabolism can play a dominant role in drug response, apoptosis and the response to stressful stimuli, and contribute to the aetiology of several pathological states, including cancer. The highly inducible enzymes SSAT (spermidine/spermine N1-acetyltransferase) and SMO (spermine oxidase) and the generally constitutively expressed APAO (N1-acetylpolyamine oxidase) appear to play critical roles in many normal… CONTINUE READING
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Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure

A. E. Pegg
Cancer Res • 2008
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Combination chemoprevention for colon cancer targeting polyamine synthesis and inflammation.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2009

Genetic and epigenetic analysis of SSAT gene dysregulation in suicidal behavior.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics • 2009

N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging

I. Stanic, A. Facchini, R. M. Borzi, C. Stefanelli, F. Flamigni
J. Cell. Mol. Med • 2009

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