Polyamine catabolism and disease.

  title={Polyamine catabolism and disease.},
  author={Robert Anthony Casero and Anthony E. Pegg},
  journal={The Biochemical journal},
  volume={421 3},
In addition to polyamine homoeostasis, it has become increasingly clear that polyamine catabolism can play a dominant role in drug response, apoptosis and the response to stressful stimuli, and contribute to the aetiology of several pathological states, including cancer. The highly inducible enzymes SSAT (spermidine/spermine N1-acetyltransferase) and SMO (spermine oxidase) and the generally constitutively expressed APAO (N1-acetylpolyamine oxidase) appear to play critical roles in many normal… CONTINUE READING
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Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure

A. E. Pegg
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N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging

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