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Sch 28080

Known as: Imidazo(1,2-a)pyridine-3-acetonitrile, 2-methyl-8-(phenylmethoxy)-, S28080, Schering compound 28080 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Proton pump inhibitors (PPIs) are widely used in the treatment of acid-related diseases. However, several unmet medical needs… Expand
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Highly Cited
1999
Highly Cited
1999
NHE3 is the predominant isoform responsible for apical membrane Na(+)/H(+) exchange in the proximal tubule. Deletion of NHE3 by… Expand
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Highly Cited
1996
Highly Cited
1996
The functional properties and the pharmacological profile of the recently cloned cDNA colonic P-ATPase α subunit (Crowson, M. S… Expand
Highly Cited
1994
Highly Cited
1994
Adenosinetriphosphatase (ATPase) activity stimulated by K+ and inhibited by Sch-28080 (SCH), omeprazole (OME), and vanadate has… Expand
Highly Cited
1993
Highly Cited
1993
Mammalian cells generally regulate their intracellular pH (pHi) via collaboration between Na(+)-H+ exchanger and HCO3- transport… Expand
Highly Cited
1988
Highly Cited
1988
A vanadate- and N-ethylmaleimide-sensitive ATPase was purified about 500-fold from chromaffin granule membranes. The purified… Expand
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Highly Cited
1988
Highly Cited
1988
SCH 28080 (2-methyl-8-(phenylmethoxy)imidazo[1,2-a] pyridine-3-acetonitrile) is an effective inhibitor of acid secretion in vivo… Expand
Highly Cited
1988
Highly Cited
1988
Upon stimulation, the gastric parietal cell secretes a large quantity of isotonic HCl across its apical membrane which must be… Expand
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Highly Cited
1987
Highly Cited
1987
A hydrophobic amine, SCH 28080, 2-methyl-8-(phenylmethoxy)imidazo(1,2a)pyridine-3-acetonitrile, previously shown to inhibit… Expand
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Highly Cited
1986
Highly Cited
1986
1 The mechanism of the gastric antisecretory action of SCH 28080 has been studied utilizing two different in vitro test systems… Expand