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Proton pump inhibitors (PPIs) are widely used in the treatment of acid-related diseases. However, several unmet medical needs… Expand NHE3 is the predominant isoform responsible for apical membrane Na(+)/H(+) exchange in the proximal tubule. Deletion of NHE3 by… Expand The functional properties and the pharmacological profile of the recently cloned cDNA colonic P-ATPase α subunit (Crowson, M. S… Expand Adenosinetriphosphatase (ATPase) activity stimulated by K+ and inhibited by Sch-28080 (SCH), omeprazole (OME), and vanadate has… Expand Mammalian cells generally regulate their intracellular pH (pHi) via collaboration between Na(+)-H+ exchanger and HCO3- transport… Expand A vanadate- and N-ethylmaleimide-sensitive ATPase was purified about 500-fold from chromaffin granule membranes. The purified… Expand SCH 28080 (2-methyl-8-(phenylmethoxy)imidazo[1,2-a] pyridine-3-acetonitrile) is an effective inhibitor of acid secretion in vivo… Expand Upon stimulation, the gastric parietal cell secretes a large quantity of isotonic HCl across its apical membrane which must be… Expand A hydrophobic amine, SCH 28080, 2-methyl-8-(phenylmethoxy)imidazo(1,2a)pyridine-3-acetonitrile, previously shown to inhibit… Expand 1 The mechanism of the gastric antisecretory action of SCH 28080 has been studied utilizing two different in vitro test systems… Expand