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Sch 28080

Known as: Imidazo(1,2-a)pyridine-3-acetonitrile, 2-methyl-8-(phenylmethoxy)-, S28080, Schering compound 28080 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

Anti-Ulcer AgentEnzyme InhibitorsImidazoles

Papers overview

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Highly Cited
2018
Highly Cited
2018
Crystal structures of the gastric proton pump
The gastric proton pump—the H+, K+-ATPase—is a P-type ATPase responsible for acidifying the gastric juice down to pH 1. This… 
Highly Cited
2011
Highly Cited
2011
A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration.
Highly Cited
2002
Highly Cited
2002
SCH28080, a K+-competitive inhibitor of the gastric H,K-ATPase, binds near the M5-6 luminal loop, preventing K+ access to the ion binding domain.
Inhibition of the gastric H,K-ATPase by the imidazo[1,2-alpha]pyridine, SCH28080, is strictly competitive with respect to K+ or… 
Highly Cited
1999
Highly Cited
1999
Mechanism of proximal tubule bicarbonate absorption in NHE3 null mice.
NHE3 is the predominant isoform responsible for apical membrane Na(+)/H(+) exchange in the proximal tubule. Deletion of NHE3 by… 
Highly Cited
1997
Highly Cited
1997
K depletion modifies the properties of Sch-28080-sensitive K-ATPase in rat collecting duct.
Two distinct Sch-28080-sensitive K-adenosine triphosphatases (K-ATPases) were previously described in the rat nephron: a ouabain… 
Highly Cited
1996
Highly Cited
1996
The Rat Distal Colon P-ATPase Subunit Encodes a Ouabain-sensitive H,K-ATPase (*)
The functional properties and the pharmacological profile of the recently cloned cDNA colonic P-ATPase α subunit (Crowson, M. S… 
Highly Cited
1991
Highly Cited
1991
Identification of an extracytoplasmic region of H+,K(+)-ATPase labeled by a K(+)-competitive photoaffinity inhibitor.
Highly Cited
1988
Highly Cited
1988
Purification and properties of a vanadate- and N-ethylmaleimide-sensitive ATPase from chromaffin granule membranes.
Highly Cited
1986
Highly Cited
1986
Mechanism of gastric antisecretory effect of SCH 28080
1 The mechanism of the gastric antisecretory action of SCH 28080 has been studied utilizing two different in vitro test systems… 
Highly Cited
1983
Highly Cited
1983
Gastric antisecretory and cytoprotective activities of SCH 28080.
SCH 28080 (2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile) is a novel antiulcer agent which has both… 
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