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Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits
The ion-selective permeability, the gating properties and the pharmacological profile of the channel formed by coexpressing the three subunits in oocytes are similar to that of the native channel.
CFTR as a cAMP-dependent regulator of sodium channels
In CF airway epithelia, the absence of this second function of CFTR as a cAMP-dependent regulator likely accounts for abnormal sodium transport.
Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron.
- J. Loffing, D. Loffing-Cueni, +6 authors B. Kaissling
- Chemistry, MedicineAmerican journal of physiology. Renal physiology
- 1 December 2001
DCT2 and CNT are disclosed as major sites for transcellular Ca(2+) transport in the mouse distal nephron, which suggests their mutual interactions in transport regulation.
Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1
Investigation of affected offspring of consanguineous union reveals mutations in either the α or β subunits of the amiloride-sensitive epithelial sodium channel in five kindreds that demonstrate the molecular basis and explain the pathophysiology of this disease.
An epithelial serine protease activates the amiloride-sensitive sodium channel
- V. Vallet, A. Chraibi, H. Gaeggeler, J. Horisberger, B. Rossier
- Medicine, BiologyNature
- 9 October 1997
This work cloned a 329-residue protein belonging to the serine protease family and shows that coexpression of this protein with ENaC in Xenopus oocytes increases the activity of the sodiumchannel by two- to threefold.
Epithelial sodium channel related to proteins involved in neurodegeneration
The gene encoding this rat sodium channel subunit shares significant sequence similarity with mec-4 and deg-1, members of a family of Caenorhabditis elegans genes involved in sensory touch transduction and, when mutated, neuronal degeneration, and it is proposed that the gene products of these three genes are member of a gene family coding for cation channels.
Corticosteroid-dependent sodium transport in a novel immortalized mouse collecting duct principal cell line.
- M. Bens, V. Vallet, +5 authors A. Vandewalle
- Medicine, BiologyJournal of the American Society of Nephrology…
- 1 May 1999
This new immortalized mammalian CCD clonal cell line has retained a high level of epithelial differentiation and sodium transport stimulated by aldosterone and therefore represents a useful mammalian cell system for identifying the genes controlled by a Aldosterone.
Liddle's syndrome: Heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel
It is demonstrated that Liddle's syndrome is caused by mutations in the beta subunit of the epithelial sodium channel and have implications for the regulation of this epithelial ion channel as well as blood pressure homeostasis.
Membrane topology of the epithelial sodium channel in intact cells.
- C. Canessa, A. Mérillat, B. Rossier
- Biology, MedicineThe American journal of physiology
- 1 December 1994
The highly selective amiloride-sensitive epithelial sodium channel is formed of three homologous subunits termed alpha-, beta-, and gamma-rENaC, and all three subunits are glycosylated in a cell-free translation assay, demonstrating that they share in vitro a common pattern of membrane insertion.
Mineralocorticoid versus glucocorticoid receptor occupancy mediating aldosterone-stimulated sodium transport in a novel renal cell line.
- H. Gaeggeler, E. Gonzalez-Rodriguez, +5 authors B. Rossier
- Biology, MedicineJournal of the American Society of Nephrology…
- 1 April 2005
Within the physiologic range of aldosterone concentrations, sodium transport is predicted to be controlled by MR occupancy during circadian cycles and by MR and GR occupancy during salt restriction or acute stress.