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Gap junctions are involved in the early generation of left-right asymmetry.
It is proposed that dorsoventral differences in GJC within the early embryo are needed to consistently orient left-right asymmetry in Xenopus embryos.
Role of Membrane Potential in the Regulation of Cell Proliferation and Differentiation
Understanding the molecular and mechanistic basis of biophysical regulation will point the way toward novel ways to rationally direct cell functions, allowing us to capitalize upon the potential ofBiophysical signaling for regenerative medicine and tissue engineering.
Bioelectric controls of cell proliferation: Ion channels, membrane voltage and the cell cycle
This work reviews recent functional data on the regulation of mitosis by bioelectric signals, and the function of membrane voltage and specific potassium, sodium, and chloride ion channels in the proliferation of embryonic, somatic, and neoplastic cells.
Molecular bioelectricity: how endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo
  • M. Levin
  • Biology
    Molecular biology of the cell
  • 1 December 2014
The understanding of how patterning information is encoded in bioelectrical networks, which may require concepts from computational neuroscience, will have transformative implications for embryogenesis, regeneration, cancer, and synthetic bioengineering.
Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates
The data implicate H+-V-ATPase activity in patterning the LR axis of vertebrates and reveal mechanisms upstream and downstream of its activity, and propose a pH- and Vmem-dependent model of the early physiology of LR patterning.