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STXBP5 gene

Known as: STXBP5, TOMOSYN, syntaxin binding protein 5 
National Institutes of Health

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STXBP4 gene

Papers overview

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Highly Cited
2008
Highly Cited
2008
Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release
Neurotransmitter release from presynaptic nerve terminals is regulated by soluble NSF attachment protein receptor (SNARE) complex… 
Review
2007
Review
2007
Regulation of Membrane Fusion in Synaptic Excitation-Secretion Coupling: Speed and Accuracy Matter
Highly Cited
2007
Highly Cited
2007
Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism
Polarized exocytosis requires coordination between the actin cytoskeleton and the exocytic machinery responsible for fusion of… 
Highly Cited
2006
Highly Cited
2006
Antagonistic Regulation of Synaptic Vesicle Priming by Tomosyn and UNC-13
Highly Cited
2005
Highly Cited
2005
PKA-catalyzed phosphorylation of tomosyn and its implication in Ca2+-dependent exocytosis of neurotransmitter
Neurotransmitter is released from nerve terminals by Ca2+-dependent exocytosis through many steps. SNARE proteins are key… 
Highly Cited
2005
Highly Cited
2005
Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain
Tomosyn was previously identified as a syntaxin‐binding protein that inhibits soluble NSF (n‐ethylmaleimide‐sensitive fusion… 
Highly Cited
2004
Highly Cited
2004
Tomosyn inhibits priming of large dense-core vesicles in a calcium-dependent manner.
Neurotransmitter release is a multistep process that is coordinated by a large number of synaptic proteins and depends on proper… 
Highly Cited
2004
Highly Cited
2004
Structural Basis for the Inhibitory Role of Tomosyn in Exocytosis*♦
Upon Ca2+ influx synaptic vesicles fuse with the plasma membrane and release their neurotransmitter cargo into the synaptic cleft… 
Highly Cited
2003
Highly Cited
2003
Tomosyn Interacts with the t-SNAREs Syntaxin4 and SNAP23 and Plays a Role in Insulin-stimulated GLUT4 Translocation*
The Sec1p-like/Munc18 (SM) protein Munc18a binds to the neuronal t-SNARE Syntaxin1A and inhibits SNARE complex assembly. Tomosyn… 
Highly Cited
1998
Highly Cited
1998
Tomosyn: a Syntaxin-1–Binding Protein that Forms a Novel Complex in the Neurotransmitter Release Process
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