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N- to C-Terminal SNARE Complex Assembly Promotes Rapid Membrane Fusion
Assembly of the soluble N-ethylmaleimide–sensitive factor attachment protein receptors (SNAREs) syntaxin 1, SNAP-25, and synaptobrevin 2 is thought to be the driving force for the exocytosis of… Expand
Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin*
- S. W. Chan, C. J. Lim, Y. F. Chong, A. Pobbati, Caixia Huang, W. Hong
- Medicine, Biology
- The Journal of Biological Chemistry
- 11 January 2011
The Hippo pathway restricts the activity of transcriptional co-activators TAZ and YAP by phosphorylating them for cytoplasmic sequestration or degradation. In this report, we describe an independent… Expand
Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes.
The structure of the complex between the transcription cofactor Vgll1 and the transcription factor TEAD4, the mammalian equivalent of the Drosophila Vestigial and Scalloped, respectively, is… Expand
Emerging roles of TEAD transcription factors and its coactivators in cancers
TEAD proteins are transcription factors that are crucial for development, but also play a role in cancers. Several developmentally and pathologically important genes are upregulated by TEADs. TEADs… Expand
Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24.
The ESCRT machinery mediates sorting of ubiquitinated transmembrane proteins to lysosomes via multivesicular bodies (MVBs) and also has roles in cytokinesis and viral budding. The ESCRT-III subunits… Expand
Agrin as a Mechanotransduction Signal Regulating YAP through the Hippo Pathway.
The Hippo pathway effectors YAP and TAZ act as nuclear sensors of mechanical signals in response to extracellular matrix (ECM) cues. However, the identity and nature of regulators in the ECM and the… Expand
Structural Basis for the Inhibitory Role of Tomosyn in Exocytosis*♦
- A. Pobbati, A. Razeto, Matthias Böddener, Stefan Becker, D. Fasshauer
- Biology, Medicine
- Journal of Biological Chemistry
- 5 November 2004
Upon Ca2+ influx synaptic vesicles fuse with the plasma membrane and release their neurotransmitter cargo into the synaptic cleft. Key players during this process are the Q-SNAREs syntaxin 1a and… Expand
Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy.
The human TEAD family of transcription factors (TEAD1-4) is required for YAP-mediated transcription in the Hippo pathway. Hyperactivation of TEAD's co-activator YAP contributes to tissue overgrowth… Expand
A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis.
Endothelial cell (EC) recruitment is central to the vascularization of tumors. Although several proteoglycans have been implicated in cancer and angiogenesis, their roles in EC recruitment and… Expand
VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle
- N. Figeac, Abdalla D. Mohamed, +15 authors H. Wackerhage
- Biology, Medicine
- Journal of Cell Science
- 1 July 2019
ABSTRACT VGLL proteins are transcriptional co-factors that bind TEAD family transcription factors to regulate events ranging from wing development in fly, to muscle fibre composition and immune… Expand