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Regulated transport of the glucose transporter GLUT4
In muscle and fat cells, insulin stimulates the delivery of the glucose transporter GLUT4 from an intracellular location to the cell surface, where it facilitates the reduction of plasma glucose…
Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat
The results suggest that in the presence of insulin GLUT 4 recycles from the cell surface, probably via the coated pit-endosome pathway that has been characterized for cell surface receptors, and also that insulin causes the redistribution ofGLUT 4 by stimulating exocytosis from GLUT 2-containing tubulo-vesicular structures, rather than by slowing endocytotic of GLUT 3.
Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase
It is demonstrated that acute IL- 6 treatment enhances insulin-stimulated glucose disposal in humans in vivo, while the effects of IL-6 on glucose and fatty acid metabolism in vitro appear to be mediated by AMPK.
Characterization of the Role of the Rab GTPase-activating Protein AS160 in Insulin-regulated GLUT4 Trafficking*
Findings support an important role for AS160 in the insulin regulated trafficking of GLUT4, which is mediated by the cytosolic tail of insulin-regulated aminopeptidase which interacted both in vitro and in vivo with AS160.
Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action.
Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States
It is suggested that berberine displays beneficial effects in the treatment of diabetes and obesity at least in part via stimulation of AMPK activity.
Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2
Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events
Data show that combinatorial interactions of SNAREs determine whether late endosomes undergo homotypic or heterotypic fusion events, and that the same Q‐SNAREs can combine with an alternative R‐ SNARE, namely VAMP7, for heterotyping fusion between late endOSomes and lysosomes.
Identification of a novel glucose transporter-like protein-GLUT-12.
- S. Rogers, Maria L. Macheda, J. Best
- BiologyAmerican journal of physiology. Endocrinology and…
- 1 March 2002
Facilitative glucose transporters exhibit variable hexose affinity and tissue-specific expression. These characteristics contribute to specialized metabolic properties of cells. Here we describe the…
GLUT4 recycles via a trans-Golgi network (TGN) subdomain enriched in Syntaxins 6 and 16 but not TGN38: involvement of an acidic targeting motif.
GLUT4 is rapidly transported from the cell surface to a subdomain of the trans-Golgi network that is enriched in the t-SNAREs Syntaxins 6 and 16 and that an acidic targeting motif in the C-terminal tail of GLUT4 plays an important role in this process.