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Neuroligins Determine Synapse Maturation and Function
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Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles
TLDR
It is shown that glutamatergic hippocampal neurons from mice lacking Munc13-1 form ultrastructurally normal synapses whose synaptic-vesicle cycle is arrested at the maturation step, demonstrating the existence of multiple and transmitter-specific synaptic vesicle maturation processes in synapses.
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Activity-Dependent Validation of Excitatory versus Inhibitory Synapses by Neuroligin-1 versus Neuroligin-2
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Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming
TLDR
It is concluded that Munc13-mediated vesicle priming is not a transmitter specific phenomenon but rather a general and essential feature of multiple fast neurotransmitter systems, and that synaptogenesis during development is not dependent on synaptic secretory activity.
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Neuroligin 2 Drives Postsynaptic Assembly at Perisomatic Inhibitory Synapses through Gephyrin and Collybistin
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β Phorbol Ester- and Diacylglycerol-Induced Augmentation of Transmitter Release Is Mediated by Munc13s and Not by PKCs
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An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size.
TLDR
The results show that the expression level of VGLUTs determines the amount of glutamate that is loaded into vesicles and released and thereby regulates the efficacy of neurotransmission.
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Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins
TLDR
Four Syts are described, three of which (Syt VI, VII and VIII) are widely expressed in non-neural tissues and appear to be ubiquitous proteins with a role in exocytosis mediated by syntaxin binding.
View on Springer
Synaptotagmin: a calcium sensor on the synaptic vesicle surface.
TLDR
It is reported here that synaptotagmin, a highly conserved synaptic vesicle protein, binds calcium at physiological concentrations in a complex with negatively charged phospholipids, and this binding is specific for calcium and involves the cytoplasmic domain of synaptoagmin.
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Functional Interaction of the Active Zone Proteins Munc13-1 and RIM1 in Synaptic Vesicle Priming
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