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SSPN protein, human

Known as: SPN1, SPN2, Kirsten-Ras-Associated Protein 
Sarcospan (1304 aa, 144 kD) is a cell adhesion process protein that is encoded by the human SSPN gene and has roles in muscle contraction and cell… 
National Institutes of Health

Related topics

Related topics

10 relations

Broader (3)

Carrier ProteinsMembrane ProteinsNeoplasm Proteins
Cell-Matrix JunctionIntegral Membrane ProteinsLigand BindingMuscle Contraction

Papers overview

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Highly Cited
2012
Highly Cited
2012
Sarcospan-dependent Akt activation is required for utrophin expression and muscle regeneration
Sarcospan signals through Akt to increase cell surface levels of utrophin and glycosylated α-dystroglycan and promote muscle… 
Highly Cited
2009
Highly Cited
2009
Crystal Structure of the Nuclear Export Receptor CRM1 in Complex with Snurportin1 and RanGTP
Nuclear Import/Export Receptor Nuclear transport receptors constantly shuttle cargo between the nucleus and the cytoplasm through… 
2008
2008
Gene expression in mouse brain following chronic hypoxia: role of sarcospan in glial cell death.
Hypoxia is a hallmark of respiratory, neurological, or hematological diseases as well as life at high altitude. For example… 
Highly Cited
2007
Highly Cited
2007
Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells
Basic transcription factor 3 (BTF3) acts as a transcription factor and modulator of apoptosis, and is differentially expressed in… 
Highly Cited
2006
Highly Cited
2006
Spirochaeta coccoides sp. nov., a Novel Coccoid Spirochete from the Hindgut of the Termite Neotermes castaneus
ABSTRACT A novel spirochete strain, SPN1, was isolated from the hindgut contents of the termite Neotermes castaneus. The highest… 
Highly Cited
2001
Highly Cited
2001
Prevention of cardiomyopathy in mouse models lacking the smooth muscle sarcoglycan-sarcospan complex.
Cardiomyopathy is a multifactorial disease, and the dystrophin-glycoprotein complex has been implicated in the pathogenesis of… 
Highly Cited
2000
Highly Cited
2000
Biochemical evidence for association of dystrobrevin with the sarcoglycan-sarcospan complex as a basis for understanding sarcoglycanopathy.
The sarcoglycan complex is composed of four membrane-spanning dystrophin-associated proteins (DAPs) and is essential for skeletal… 
Highly Cited
1999
Highly Cited
1999
Loss of the sarcoglycan complex and sarcospan leads to muscular dystrophy in beta-sarcoglycan-deficient mice.
beta-Sarcoglycan, one of the subunits of the sarcoglycan complex, is a transmembranous glycoprotein which associates with… 
Highly Cited
1999
Highly Cited
1999
Biochemical Characterization of the Epithelial Dystroglycan Complex*
Dystroglycan is a widely expressed extracellular matrix receptor that plays a critical role in basement membrane formation… 
1996
1996
Coamplification in tumors of KRAS2, type 2 inositol 1,4,5 triphosphate receptor gene, and a novel human gene, KRAG.
Analysis of a region of DNA, coamplified in tumors with KRAS2, resulted in the identification of the human homologue of the mouse… 
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