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SRD5A2 gene

Known as: Steroid-5-Alpha-Reductase, Alpha Polypeptide 2 (3-oxo-5 Alpha-Steroid Delta 4-Dehydrogenase Alpha 2) Gene, 3-oxo-5-alpha-steroid 4-dehydrogenase 2, SRD5A2 
This gene is involved in androgen metabolism and sexual differentiation.
National Institutes of Health

Related topics

Related topics

4 relations
Androgen Metabolism ProcessHypospadiasOxidation-ReductionTestosterone 5-alpha-Reductase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Clinical characteristics and genotype‐phenotype correlations of 130 Chinese children in a high‐homogeneity single‐center cohort with 5α‐reductase 2 deficiency
Patients with steroid 5α‐reductase 2 deficiency (5α‐RD) caused by SRD5A2 (OMIM #607306) variants present variable genotypes and… 
2015
2015
DNA methyl transferase 1 reduces expression of SRD5A2 in the aging adult prostate.
2014
2014
AR and SRD5A2 gene mutations in a series of 51 Turkish 46,XY DSD children with a clinical diagnosis of androgen insensitivity
46,XY disorders of sex development (DSD) are caused by disorders of gonadal development, androgen biosynthesis and receptor (AR… 
2012
2012
Variants in the SRD5A2 gene are associated with quality of semen.
Spermatogenesis and sperm maturation are androgen-dependent processes. Steroid 5α-reductase (SRD5A) is a key enzyme… 
2010
2010
Molecular analysis of the SRD5A2 in 46,XY subjects with incomplete virilization: the P212R substitution of the steroid 5alpha-reductase 2 may constitute an ancestral founder mutation in Mexican…
Inactivating mutations of the SRD5A2 gene result in steroid 5α-reductase 2 deficiency, an autosomal recessive disorder expressed… 
2010
2010
Association of SRD5A2 variants and serum androstane-3alpha,17beta-diol glucuronide concentration in Chinese elderly men.
BACKGROUND Results of recent studies have demonstrated that genetic variants of the enzyme steroid 5α reductase type II (SRD5A2… 
2009
2009
The assessment of methylated BASP1 and SRD5A2 levels in the detection of early hepatocellular carcinoma.
We previously identified BASP1 and SRD5A2 as novel hepatocellular carcinoma (HCC) methylation markers from among more than 10,000… 
2008
2008
Identification of novel aberrant methylation of BASP1 and SRD5A2 for early diagnosis of hepatocellular carcinoma by genome-wide search.
A genome-wide study using expression profiles of 12,600 genes was conducted to identify methylated genes that could be used for… 
2008
2008
Novel compound heterozygous mutations in the SRD5A2 gene from 46,XY infants with ambiguous external genitalia
AbstractDihydrotestosterone is crucial for normal development of external genitalia and prostate in the male embryo. Autosomal… 
Highly Cited
2001
Highly Cited
2001
Impact of genetic polymorphisms of 17‐hydroxylase cytochrome P‐450 (CYP17) and steroid 5α‐reductase type II (SRD5A2) genes on prostate‐cancer risk among the Japanese population
Steroid hormones, especially testosterone, play important roles in the carcinogenesis of prostate cancer, and several studies… 
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