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SRD5A2 gene

Known as: Steroid-5-Alpha-Reductase, Alpha Polypeptide 2 (3-oxo-5 Alpha-Steroid Delta 4-Dehydrogenase Alpha 2) Gene, 3-oxo-5-alpha-steroid 4-dehydrogenase 2, SRD5A2 
This gene is involved in androgen metabolism and sexual differentiation.
National Institutes of Health

Related topics

Related topics

4 relations
Androgen Metabolism ProcessHypospadiasOxidation-ReductionTestosterone 5-alpha-Reductase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
In silico screening of potential lead compounds against 3-oxo-5-alpha-steroid 4-dehydrogenase 2 for treating prostate cancer.
Increased levels of androgen dihydrotestosterone is responsible for the development of prostate cancer in humans. The formation… 
2019
2019
Altered methylation pattern of the SRD5A2 gene in cerebrospinal fluid of post- Finasteride patients: a pilot study
1Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy; 2Unit of Endocrinology… 
2015
2015
Abstract 1052: Variable expression of 5-alpha reductase 2 in the aging adult prostate is regulated by DNA methylation
BACKGROUND: 5-alpha reductase type 2 (SRD5A2), an enzyme that is critical for prostatic development and growth, is utilized as an… 
2014
2014
AB215. Variants in the SRD5A2 gene are associated with quality of semen
Spermatogenesis and sperm maturation are androgen-dependent processes. Steroid 5α-reductase (SRD5A) is a key enzyme converting… 
2013
2013
Mutation analysis of the SRD5A2, AR and SF-1 genes in 52 Chinese boys with hypospadias
Abstract Objectives: To investigate the prevalence of genetic mutations in steroid 5α-reductase-2 (SRD5A2), androgen receptor (AR… 
2013
2013
Abstract 2976: Dynamic expression of 5-alpha reductase 2 in aging prostate is regulated by DNA methyltransferase 1.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Introduction: 5-alpha reductase type 2 (SRD5A2), an… 
2011
2011
SRD5A polymorphisms and biochemical failure after radical prostatectomy.
2010
2010
Association of SRD5A2 variants and serum androstane-3alpha,17beta-diol glucuronide concentration in Chinese elderly men.
BACKGROUND Results of recent studies have demonstrated that genetic variants of the enzyme steroid 5α reductase type II (SRD5A2… 
2009
2009
The assessment of methylated BASP1 and SRD5A2 levels in the detection of early hepatocellular carcinoma.
We previously identified BASP1 and SRD5A2 as novel hepatocellular carcinoma (HCC) methylation markers from among more than 10,000… 
2007
2007
A Common Polymorphism of the SRD5A2 Gene and Transsexualism
The relation between genetic variation of the androgen metabolism and transsexualism is unknown. In a case-control study of 100… 
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