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Testosterone 5-alpha-Reductase

Known as: 5 alpha Reductase, Testosterone, delta4 3 ketosteroid 5alpha Oxidoreductase, 5Alpha Reductase, Steroid 
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (254 aa, ~28 kDa) is encoded by the human SRD5A2 gene. This protein plays a role in sexual differentiation… 
National Institutes of Health

Related topics

Related topics

26 relations
3-oxo-5-alpha-steroid 4-dehydrogenase activityAndrogen Metabolism ProcessBile Acid Biosynthesis PathwayCongenital adrenal hyperplasia

Broader (1)

Oxidoreductase

Narrower (3)

Pseudovaginal Perineoscrotal HypospadiasSrd5a1 protein, ratSrd5a2 protein, rat

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Predicted Exposures to Steroid Estrogens in U.K. Rivers Correlate with Widespread Sexual Disruption in Wild Fish Populations
Steroidal estrogens, originating principally from human excretion, are likely to play a major role in causing widespread… 
Review
1997
Review
1997
Comparative anatomy of the aldo-keto reductase superfamily.
The aldo-keto reductases metabolize a wide range of substrates and are potential drug targets. This protein superfamily includes… 
Review
1994
Review
1994
Steroid 5 alpha-reductase: two genes/two enzymes.
BIOCHEMICAL PROPERTIES OF STEROID Sa-REDUCTASE . . . . . . . . . . . . 30 Protein Structure… 
Highly Cited
1993
Highly Cited
1993
Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression.
The synthesis of dihydrotestosterone is catalyzed by steroid 5 alpha-reductase isozymes, designated types 1 and 2. Mutation of… 
Review
1993
Review
1993
Genetic and nongenetic determinants of regional fat distribution.
The role of inherited and nongenetic factors in individual differences observed in the level of sc fat on the trunk and abdominal… 
Highly Cited
1992
Highly Cited
1992
Molecular genetics of steroid 5 alpha-reductase 2 deficiency.
Two isozymes of steroid 5 alpha-reductase encoded by separate loci catalyze the conversion of testosterone to dihydrotestosterone… 
Highly Cited
1992
Highly Cited
1992
5-alpha-reductase activity and risk of prostate cancer among Japanese and US white and black males
Highly Cited
1992
Highly Cited
1992
Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase.
The enzyme steroid 5 alpha-reductase catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone… 
Highly Cited
1990
Highly Cited
1990
Testosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosterone.
Testosterone and dihydrotestosterone are believed to exert their androgenic effects by interacting with a single intracellular… 
Highly Cited
1990
Highly Cited
1990
Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases.
The microsomal enzyme steroid 5 alpha-reductase is responsible for the conversion of testosterone into the more potent androgen… 
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