Testosterone 5-alpha-Reductase

Known as: 5 alpha Reductase, Testosterone, delta4 3 ketosteroid 5alpha Oxidoreductase, 5Alpha Reductase, Steroid 
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (254 aa, ~28 kDa) is encoded by the human SRD5A2 gene. This protein plays a role in sexual differentiation… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1967-2017
02040608019672017

Papers overview

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Highly Cited
2011
Highly Cited
2011
In the majority of cases, advanced prostate cancer responds initially to androgen deprivation therapy by depletion of gonadal… (More)
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2000
2000
Human prostatic steroid 5alpha-reductase, encoded by the SRD5A2 gene on chromosome band 2p23, catalyses the irreversible… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Sex steroids, particularly androgens, have been implicated in the pathogenesis of prostate cancer. Data from previous… (More)
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Highly Cited
1995
Highly Cited
1995
Isoflavonoids and lignans, constituents of many plant foods, have been proposed as protective agents in those populations with a… (More)
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Highly Cited
1993
Highly Cited
1993
The synthesis of dihydrotestosterone is catalyzed by steroid 5 alpha-reductase isozymes, designated types 1 and 2. Mutation of… (More)
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Highly Cited
1992
Highly Cited
1992
The oral administration of finasteride, a 4-aza-steroid inhibitor of 5 alpha-reductase, decreases serum dihydrotestosterone… (More)
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Highly Cited
1992
Highly Cited
1992
The enzyme steroid 5 alpha-reductase catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone… (More)
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1992
1992
Two isozymes of steroid 5 alpha-reductase encoded by separate loci catalyze the conversion of testosterone to dihydrotestosterone… (More)
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Highly Cited
1991
Highly Cited
1991
The conversion of testosterone into dihydrotestosterone by steroid 5 alpha-reductase is a key reaction in androgen action, and is… (More)
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1980
1980
In order to know the distribution of testosterone 5 alpha-reductase activity in human skin, we developed a micro-method, in which… (More)
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