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Testosterone 5-alpha-Reductase

Known as: 5 alpha Reductase, Testosterone, delta4 3 ketosteroid 5alpha Oxidoreductase, 5Alpha Reductase, Steroid 
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (254 aa, ~28 kDa) is encoded by the human SRD5A2 gene. This protein plays a role in sexual differentiation… 
National Institutes of Health

Related topics

Related topics

26 relations
3-oxo-5-alpha-steroid 4-dehydrogenase activityAndrogen Metabolism ProcessBile Acid Biosynthesis PathwayCongenital adrenal hyperplasia

Broader (1)

Oxidoreductase

Narrower (3)

Pseudovaginal Perineoscrotal HypospadiasSrd5a1 protein, ratSrd5a2 protein, rat

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
1996
Review
1996
Genetic susceptibility to cancer from exogenous and endogenous exposures
The past four decades of epidemiological research have yielded valuable information on the risks of populations to environmental… 
Highly Cited
1995
Highly Cited
1995
Evidence for atrophy and apoptosis in the ventral prostate of rats given the 5 alpha-reductase inhibitor finasteride.
Castration causes cell loss in the rat ventral prostate through a process called apoptosis. Although 5 alpha-reductase inhibition… 
Highly Cited
1991
Highly Cited
1991
Creation of "super" glucocorticoid receptors by point mutations in the steroid binding domain.
Highly Cited
1985
Highly Cited
1985
The development of a male pseudohermaphroditic rat using an inhibitor of the enzyme 5 alpha-reductase.
Incomplete masculinization of the external genitalia occurred in male Sprague-Dawley rats treated with a potent inhibitor of… 
Highly Cited
1984
Highly Cited
1984
Aromatase activity in cultured human genital skin fibroblasts.
Aromatase activity of human genital skin fibroblasts grown in cell culture was studied using both [1,2,6,7-3H] androstenedione (A… 
Highly Cited
1979
Highly Cited
1979
Activation of thymocyte glucocorticoid receptors to the steroid binding form. The roles of reduction agents, ATP, and heat-stable factors.
The specific glucocorticoid binding capacity in cytosol preparations of rat thymocytes decays with a half-life of 4 h at 0… 
Highly Cited
1973
Highly Cited
1973
STUDIES IN PORPHYRIA
Patients with the genetic liver disease, acute intermittent porphyria (AIP), have a defect in the reductive transformation of… 
Highly Cited
1968
Highly Cited
1968
Cytochrome P-450 and steroid biosynthesis in the human placenta.
Highly Cited
1966
Highly Cited
1966
Bioconversion of steroids in immature rat testes in vitro.
Among the testicular enzymes related to steroid bioconversion, the Δ5-3β-hydroxysteroid dehydrogenase, together with the… 
Highly Cited
1960
Highly Cited
1960
Some Characteristics of the Microsomal Steroid Reductases (5α) of Rat Liver
We have reported the presence, in rat liver microsomes, of many A4-3-ketosteroid reductases (50() which catalyze the… 
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