FAQ

Bile Acid Biosynthesis Pathway

Known as: Primary bile acid biosynthesis, bile acid formation, bile acid anabolism 
The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. [GOC… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1957-2018
05019572017

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11 relations
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Related mentions per year

1947-2018
19401960198020002020
Bile Acid Biosynthesis Pathway
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Papers overview

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Highly Cited
2013
Highly Cited
2013
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist.
Bile acids are synthesized from cholesterol in the liver and further metabolized by the gut microbiota into secondary bile acids… (More)
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Highly Cited
2005
Highly Cited
2005
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
The liver and intestine play crucial roles in maintaining bile acid homeostasis. Here, we demonstrate that fibroblast growth… (More)
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Highly Cited
2003
Highly Cited
2003
Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis.
The nuclear bile acid receptor FXR has been proposed to play a central role in the feedback repression of the gene encoding… (More)
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Highly Cited
2001
Highly Cited
2001
Hepatocyte nuclear factor-1α is an essential regulator of bile acid and plasma cholesterol metabolism
Maturity-onset diabetes of the young type 3 (MODY3) is caused by haploinsufficiency of hepatocyte nuclear factor-1α (encoded by… (More)
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Highly Cited
2000
Highly Cited
2000
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.
Bile acids repress the transcription of cytochrome P450 7A1 (CYP7A1), which catalyzes the rate-limiting step in bile acid… (More)
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Highly Cited
2000
Highly Cited
2000
Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers.
Several nuclear hormone receptors involved in lipid metabolism form obligate heterodimers with retinoid X receptors (RXRs) and… (More)
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Highly Cited
2000
Highly Cited
2000
Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors.
The catabolism of cholesterol into bile acids is regulated by oxysterols and bile acids, which induce or repress transcription of… (More)
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Highly Cited
1999
Highly Cited
1999
Identification of a nuclear receptor for bile acids.
Bile acids are essential for the solubilization and transport of dietary lipids and are the major products of cholesterol… (More)
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Highly Cited
1998
Highly Cited
1998
Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα
We demonstrate that mice lacking the oxysterol receptor, LXR alpha, lose their ability to respond normally to dietary cholesterol… (More)
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Highly Cited
1998
Highly Cited
1998
An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway
Steroid hormones exert profound effects on differentiation, development, and homeostasis in higher eukaryotes through… (More)
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