Bile Acid Biosynthesis Pathway

Known as: Primary bile acid biosynthesis, bile acid formation, bile acid anabolism 
The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. [GOC… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1957-2018
05019572017

Papers overview

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Highly Cited
2013
Highly Cited
2013
Bile acids are synthesized from cholesterol in the liver and further metabolized by the gut microbiota into secondary bile acids… (More)
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Highly Cited
2005
Highly Cited
2005
The liver and intestine play crucial roles in maintaining bile acid homeostasis. Here, we demonstrate that fibroblast growth… (More)
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Highly Cited
2003
Highly Cited
2003
The nuclear bile acid receptor FXR has been proposed to play a central role in the feedback repression of the gene encoding… (More)
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Highly Cited
2001
Highly Cited
2001
Maturity-onset diabetes of the young type 3 (MODY3) is caused by haploinsufficiency of hepatocyte nuclear factor-1α (encoded by… (More)
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Highly Cited
2000
Highly Cited
2000
Bile acids repress the transcription of cytochrome P450 7A1 (CYP7A1), which catalyzes the rate-limiting step in bile acid… (More)
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Highly Cited
2000
Highly Cited
2000
Several nuclear hormone receptors involved in lipid metabolism form obligate heterodimers with retinoid X receptors (RXRs) and… (More)
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Highly Cited
2000
Highly Cited
2000
The catabolism of cholesterol into bile acids is regulated by oxysterols and bile acids, which induce or repress transcription of… (More)
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Highly Cited
1999
Highly Cited
1999
Bile acids are essential for the solubilization and transport of dietary lipids and are the major products of cholesterol… (More)
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Highly Cited
1998
Highly Cited
1998
We demonstrate that mice lacking the oxysterol receptor, LXR alpha, lose their ability to respond normally to dietary cholesterol… (More)
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Highly Cited
1998
Highly Cited
1998
Steroid hormones exert profound effects on differentiation, development, and homeostasis in higher eukaryotes through… (More)
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