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3-oxo-5-alpha-steroid 4-dehydrogenase activity

Known as: 4-ene-3-ketosteroid-5alpha-oxidoreductase activity, 3-oxo-5alpha-steroid delta4-dehydrogenase activity, steroid delta4-5alpha-reductase activity 
Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. [EC:1.3.99.5]
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
N-linked glycosylation is the most frequent modification of secreted and membrane-bound proteins in eukaryotic cells, disruption… Expand
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Highly Cited
2007
Highly Cited
2007
Cotton (Gossypium hirsutum L.) fibers, one of the most important natural raw materials for textile industry, are highly elongated… Expand
Highly Cited
2006
Highly Cited
2006
Biochemical changes of cervical connective tissue, including progressive disorganization of the collagen network and increased… Expand
Highly Cited
2001
Highly Cited
2001
It has been suggested that the activity of the steroid 5alpha-reductase type II enzyme (encoded by the SRD5A2 gene) may be… Expand
Highly Cited
2000
Highly Cited
2000
Human prostatic steroid 5alpha-reductase, encoded by the SRD5A2 gene on chromosome band 2p23, catalyses the irreversible… Expand
Highly Cited
1999
Highly Cited
1999
BACKGROUND Prostate cancer is a very common disease in more-developed countries, but its cause is largely unknown. It is an… Expand
Highly Cited
1999
Highly Cited
1999
Successful delivery of the fetus (parturition) depends on coordinate interactions between the uterus and cervix. A majority (70… Expand
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Highly Cited
1997
Highly Cited
1997
Prostate cancer is the most common serious cancer diagnosed in men in the United States. This disease is also characterized by a… Expand
Highly Cited
1976
Highly Cited
1976
The nature of the steroid binding site in alpha1-acid glycoprotein (orosomucoid) was investigated by chemical modification of… Expand
Highly Cited
1974
Highly Cited
1974
In male pseudohermaphrodites born with ambiguity of the external genitalia but with marked virilization at puberty, biochemical… Expand