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3-oxo-5-alpha-steroid 4-dehydrogenase activity

Known as: 4-ene-3-ketosteroid-5alpha-oxidoreductase activity, 3-oxo-5alpha-steroid delta4-dehydrogenase activity, steroid delta4-5alpha-reductase activity 
Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. [EC:1.3.99.5]
National Institutes of Health

Related topics

Related topics

3 relations
Testosterone 5-alpha-Reductasecholestenone 5 alpha-reductase

Narrower (1)

cholestenone 5-alpha-reductase activity

Papers overview

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Highly Cited
2010
Highly Cited
2010
SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder
Highly Cited
2009
Highly Cited
2009
DMLC motion tracking of moving targets for intensity modulated arc therapy treatment – a feasibility study
Purpose. Intensity modulated arc therapy offers great advantages with the capability of delivering a fast and highly conformal… 
Highly Cited
2006
Highly Cited
2006
Timing of Neutrophil Activation and Expression of Proinflammatory Markers Do Not Support a Role for Neutrophils in Cervical Ripening in the Mouse1
Abstract The mechanisms that facilitate remodeling of the cervix in preparation for and during parturition remain poorly… 
Highly Cited
2001
Highly Cited
2001
Polymorphic markers in the SRD5A2 gene and prostate cancer risk: a population-based case-control study.
It has been suggested that the activity of the steroid 5alpha-reductase type II enzyme (encoded by the SRD5A2 gene) may be… 
Highly Cited
2001
Highly Cited
2001
A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives.
Highly Cited
2000
Highly Cited
2000
Biochemical and pharmacogenetic dissection of human steroid 5 alpha-reductase type II.
Human prostatic steroid 5alpha-reductase, encoded by the SRD5A2 gene on chromosome band 2p23, catalyses the irreversible… 
Highly Cited
1999
Highly Cited
1999
Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles, USA
Highly Cited
1997
Highly Cited
1997
A prevalent missense substitution that modulates activity of prostatic steroid 5alpha-reductase.
Prostate cancer is the most common serious cancer diagnosed in men in the United States. This disease is also characterized by a… 
Highly Cited
1997
Highly Cited
1997
Characterization of cholesterol oxidase from Streptomyces hygroscopicus and Brevibacterium sterolicum.
The FAD-containing enzyme cholesterol oxidase catalyzes the oxidation and isomerization of 3beta-hydroxysteroids having a trans… 
Highly Cited
1976
Highly Cited
1976
Steroid-protein interactions. XXXIV. Chemical modification of alpha1-acid glycoprotein for characterization of the progesterone binding site.
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