Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles, USA

@article{Makridakis1999AssociationOM,
  title={Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles, USA},
  author={N. Makridakis and R. Ross and M. Pike and L. Crocitto and Jurgen KV Reichardt},
  journal={The Lancet},
  year={1999},
  volume={354},
  pages={975-978}
}
  • N. Makridakis, R. Ross, +2 authors Jurgen KV Reichardt
  • Published 1999
  • Medicine
  • The Lancet
  • BACKGROUND Prostate cancer is a very common disease in more-developed countries, but its cause is largely unknown. It is an androgen-dependent cancer, and androgens have been proposed as having a substantial role in predisposition to the disease. Thus, variations in androgen metabolism genes may affect risk of this disease. METHODS We screened 216 African-American and 172 Hispanic men with prostate cancer, and 261 African-American and 200 Hispanic healthy men (controls), from a large… CONTINUE READING
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