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Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
- K. Estrada, U. Styrkarsdottir, +178 authors F. Rivadeneira
- Medicine, Biology
- Nature Genetics
- 9 April 2012
Light is shed on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility and within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. Expand
Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: A proton MR spectroscopy study
- D. Yeung, J. Griffith, G. Antonio, F. H. Lee, J. Woo, P. Leung
- Journal of magnetic resonance imaging : JMRI
- 1 August 2005
To use proton magnetic resonance spectroscopy (1H‐MRS) to evaluate vertebral marrow fat, and to determine whether bone density correlates with fat content and fat unsaturation levels in… Expand
Vertebral marrow fat content and diffusion and perfusion indexes in women with varying bone density: MR evaluation.
The subjects experienced a decrease in vertebral marrow maximum enhancement and enhancement slope and an increase in marrow fat content as bone density decreased and the reduction in perfusion indexes occurred only within the vertebral body and not in the paravertebral tissues supplied by the same artery. Expand
Modified Pfirrmann Grading System for Lumbar Intervertebral Disc Degeneration
The modified Pfirrmann grading system is useful at discriminating severity of disc degeneration in elderly subjects and can be applied with good intra- and interobserver agreement. Expand
Vertebral bone mineral density, marrow perfusion, and fat content in healthy men and men with osteoporosis: dynamic contrast-enhanced MR imaging and MR spectroscopy.
Subjects with osteoporosis have decreased vertebral marrow perfusion and increased marrow fat compared with these parameters in subjects with osteopenia and subjects with normal bone density. Expand
Prevalence of Musculoskeletal Symptoms in Single and Multiple Body Regions and Effects of Perceived Risk of Injury Among Manual Handling Workers
Musculoskeletal symptoms were the most frequent among manual handling workers, followed by the shoulders, then the upper back, hips-upper legs, and neck, and Finger symptoms had the lowest prevalence values. Expand
Fluid conductance of cancellous bone graft as a predictor for graft-host interface healing.
Data from rabbit model supported the hypothesis that the fluid conductance of cancellous bone graft is a deciding factor in graft-host union and a threshold conductance was found to be 1.5 x 10(-10) m3 s-1 Pa-1, below which revascularisation and the formations of osteoblasts and fibrous tissues could not be attained. Expand
Telomeres and frailty
- J. Woo, N. Tang, E. Suen, J. Leung, P. Leung
- Biology, Medicine
- Mechanisms of Ageing and Development
- 1 November 2008
While telomere length may be a biomarker of cellular senescence, this relationship may not be extrapolated to the functional level represented by the frailty phenotype. Expand
Association between serum 25-hydroxyvitamin D and psychological health in older Chinese men in a cohort study.
Serum 25OHD was inversely associated with depression at baseline and was not linked to baseline cognitive impairment and 4-year incident depression in Chinese older men. Expand
Normal ranges for vertebral height ratios and prevalence of vertebral fracture in hong kong chinese: A comparison with American caucasians
- E. Lau, H. Chan, +4 authors P. Leung
- Journal of bone and mineral research : the…
- 1 September 1996
It is concluded that population‐specific means and SD should be used for defining vertebral fracture and that the prevalence of vertebral fractures is similar in Hong Kong Chinese and American Caucasians. Expand